OLFM4 Proteins, Antibodies, cDNA Clones Research Reagents

OLFM4 (Olfactomedin 4, also known as GC1; OLM4; OlfD; GW112; hGC-1; hOLfD; UNQ362; bA209J19.1), located on 13q14.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 57280 Da protein composed of 510 amino acids. This gene was originally cloned from human myeloblasts and found to be selectively expressed in inflamed colonic epithelium. Diseases such as Pancreatic Cancer and Ovary Serous Adenocarcinoma are associated with OLFM4. The related pathways of OLFM4 include Innate Immune System and Adhesion.

OLFM4 Protein (1)

    OLFM4 Antibody (2)

      OLFM4 cDNA Clone (9)


      In lentiviral vector

      OLFM4 qPCR Primer (1)

      OLFM4 Lysate (1)

        OLFM4 の背景知識

        Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein that contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote the proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed in some human tumor types, especially in those of the digestive system. GW112 is associated with GRIM-19, a protein known to be involved in regulating cellular apoptosis. Functionally, GW112 could significantly attenuate the ability of GRIM19 to mediate retinoic acid-IFN-beta-mediated cellular apoptosis and apoptosis-related gene expression. Also, GW112 demonstrated strong antiapoptotic effects in tumor cells treated with other stress exposures such as hydrogen peroxide. Finally, forced overexpression of GW112 in murine prostate tumor cells led to more rapid tumor formation in a syngeneic host. OLFM4 is an important regulator of cell death that plays important roles in tumor cell survival and tumor growth. As a candidate gene for cancer-specific expression. The serum olfactomedin 4 (OLFM4) is a useful marker for Gastric cancer (GC) and its measurement alone or in combination with Reg IV has utility in the early detection of GC. GW112 has an antiapoptotic property against the cytotoxic agents-induced apoptosis. It suggested that GW112 could be an important mediator in NF kappaB-dependent tumorigenesis of digestive tract tissues.

        OLFM4 の参考文献

        • Zhang X, et al. (2004) GW112, a novel antiapoptotic protein that promotes tumor growth. Cancer Res. 64(7): 2474-81.
        • Koshida S, et al. (2007) Specific overexpression of OLFM4(GW112/HGC-1) mRNA in colon, breast and lung cancer tissues detected using quantitative analysis. Cancer Sci. 98(3): 315-20.
        • Oue N, et al. (2009) Serum olfactomedin 4 (GW112, hGC-1) in combination with Reg IV is a highly sensitive biomarker for gastric cancer patients. Int J Cancer. 125(10): 2383-92.
        • Kim KK, et al. (2010) Up regulation of GW112 Gene by NF kappaB promotes an antiapoptotic property in gastric cancer cells. Mol Carcinog. 49(3): 259-70.

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