OLAH/oleoyl-ACP hydrolase Antibodies, cDNA Clones Research Reagents

OLAH (Oleoyl-ACP Hydrolase, also known as TE2; SAST; AURA1; THEDC1), located on 10p13, is a Protein Coding gene. The gene produces a 29931 Da protein composed of 265 amino acids. This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. OLAH contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). Diseases such as Rheumatoid Arthritis and Arthritis are associated with OLAH.

OLAH/oleoyl-ACP hydrolase Antibody (1)

    OLAH/oleoyl-ACP hydrolase cDNA Clone (15)

    BC050372

    クローニングベクター cDNA 製品

    In lentiviral vector

    OLAH/oleoyl-ACP hydrolase qPCR Primer (1)

    OLAH/oleoyl-ACP hydrolase の背景知識

    OLAH (Oleoyl-ACP Hydrolase) is a Protein Coding gene. The OLAH gene, located on 10p13, is conserved in chimpanzee, mouse, rat, chicken, zebrafish, and frog. This enzyme belongs to the family of hydrolases, specifically those acting on thioester bonds. The systematic name of this enzyme class is oleoyl-[acyl-carrier-protein] hydrolase. OLAH contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16). Diseases associated with OLAH include Rheumatoid Arthritis and Arthritis. Among its related pathways are Fatty acid biosynthesis (KEGG) and Metabolism. 204 organisms have orthologs with the human gene OLAH.

    OLAH/oleoyl-ACP hydrolase の参考文献

    • Ritchie MK, et al. (2016) Crystal structure and substrate specificity of human thioesterase 2: Insights into the molecular basis for the modulation of fatty acid synthase. J Biol Chem 291 (7): 3520-3530.
    • Khanna R, et al. (2018) E3 ubiquitin ligase rnf123 targets lamin b1 and lamin-binding proteins. Febs j 285 (12): 2243-2262.
    • Grupe A, et al. (2006) A scan of chromosome 10 identifies a novel locus showing strong association with late-onset alzheimer disease. Am J Hum Genet 78 (1): 78-88.

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