OGFR Antibodies, cDNA Clones Research Reagents

OGFR (Opioid Growth Factor Receptor), located on 20q13.33, is a Protein Coding gene. The protein encoded by this gene is a receptor for an opioid growth factor (OGF), also known as [Met(5)]-enkephalin. The gene produces a 73325 Da protein composed of 677 amino acids. OGFR is a receptor for [Met(5)]-enkephalin and plays important role in the regulation of cell growth and embryonic development. The function of the OGF-OGFr axis requires the receptor to translocate to the nucleus. Diseases such as Keratopathy and Malignant Granular Cell Myoblastoma are associated with OGFR.

OGFR Antibody (2)

    OGFR cDNA Clone (15)

    NM_031373.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    OGFR qPCR Primer (1)

    OGFR の背景知識

    Opioid growth factor receptor (OGFR) is a receptor for [Met(5)]-enkephalin and plays important role in the regulation of cell growth and embryonic development. Opioid growth factor receptor (OGFr) facilitates growth inhibition in the presence of its specific ligand opioid growth factor (OGF), chemically termed [Met(5)]-enkephalin. The function of the OGF-OGFr axis requires the receptor to translocate to the nucleus. The opioid growth factor (OGF)-OGF receptors (OGFr) axis plays an important role in the homeostasis and re-epithelialization of the mammalian cornea. This tonically active growth regulatory inhibitory pathway is involved in cell replication, and the endogenous neuropeptide OGF targets cyclin-dependent kinase inhibitors, p16 and/or p21. The opioid growth factor receptor (OGFr) mediates the inhibitory action of OGF on cell replication of normal and neoplastic cells.

    OGFR の参考文献

    • Thakur NA, et al. (2016) Antagonism of the met5-enkephalin-opioid growth factor receptor-signaling axis promotes msc to differentiate into osteoblasts. J Orthop Res 34 (7): 1195-1205.
    • McLaughlin PJ, et al. (2010) Diabetic keratopathy and treatment by modulation of the opioid growth factor (ogf)-ogf receptor (ogfr) axis with naltrexone: A review. Brain Res Bull 81 (2-3): 236-247.
    • Kren NP, et al. (2016) Featured article: Nuclear export of opioid growth factor receptor is crm1 dependent. Exp Biol Med (Maywood) 241 (3): 273-281.
    • Guo Y, et al. (2013) An opioid growth factor receptor (ogfr) for [met5]-enkephalin in chlamys farreri. Fish Shellfish Immunol 34 (5): 1228-1235.

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