Ovarian cancer immunoreactive antigen domain containing 2 (OCIAD2) is a Protein Coding gene. The OCIAD2 gene, located on 4p11, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. Frequently methylated or downregulated, OCIAD2 has been observed in kinds of tumors, and TGFβ signaling has been proved to induce the expression of OCIAD2. OCIAD2 has been found frequently methylated in various cancers, including hepatocellular carcinoma (HCC). OCIAD2 has also been reported to show cancer-specific expression in early invasive lung adenocarcinoma. Diseases associated with OCIAD2 include Ovarian Mucinous Neoplasm and Ovarian Cancer. An important paralog of this gene is OCIAD1. 210 organisms have orthologs with the human gene OCIAD2.