Occludin Antibodies, cDNA Clones Research Reagents

OCLN (Occludin, also known as BLCPMG; PTORCH1; PPP1R115), located on 5q13.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, zebrafish, and frog. The gene produces a 59144 Da protein composed of 522 amino acids. This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. Diseases such as Pseudo-Torch Syndrome 1 and Torch Syndrome are associated with OCLN. The related pathways of OCLN include Blood-Brain Barrier and Immune Cell Transmigration: VCAM-1/CD106 Signaling and Pathogenic Escherichia coli infection.

Occludin Antibody (2)

    Occludin cDNA Clone (13)

    BC029886

    クローニングベクター cDNA 製品

    In lentiviral vector

    Occludin qPCR Primer (1)

    Occludin の背景知識

    OCLN (Occludin) is a Protein Coding gene. This gene encodes an integral membrane protein that is required for cytokine-induced regulation of the tight junction paracellular permeability barrier. It belongs to the ELL/occludin family. OCLN is an important component of the tight junction complex, providing apical intercellular connections between adjacent cells in endothelial and epithelial tissue. OCLN, an integral tight junction protein, is one of the key factors for HCV entry into cells. OCLN, a key receptor for HCV, is a candidate target of miR-122; the most abundant hepatic micro RNA. Over-expression of miR-122 can decrease HCV entry into hepatocytes through down-regulation of OCLN. Diseases associated with OCLN include Pseudo-Torch Syndrome 1 and Torch Syndrome.

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