OAS2 Antibodies, cDNA Clones Research Reagents

OAS2 (2'-5'-Oligoadenylate Synthetase 2), located on 12q24.13, is a Protein Coding gene. This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The gene produces an 82431 Da protein composed of 719 amino acids. OAS2 has been known as an antiviral interferon-stimulated gene (ISG). The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). Diseases such as Tick-Borne Encephalitis and Microphthalmia With Limb Anomalies are associated with OAS2.

OAS2 Antibody (1)

    OAS2 cDNA Clone (15)

    BC049215

    クローニングベクター cDNA 製品

    In lentiviral vector

    OAS2 qPCR Primer (1)

    OAS2 の背景知識

    OAS2 (2'-5'-Oligoadenylate Synthetase 2) is a Protein Coding gene. The OAS2 gene, located on 12q24.13, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, and rat. OAS2 has been known as an antiviral interferon-stimulated gene (ISG). This gene encodes a member of the 2-5A synthetase family, essential proteins involved in the innate immune response to viral infection. The encoded protein is induced by interferons and uses adenosine triphosphate in 2'-specific nucleotidyl transfer reactions to synthesize 2',5'-oligoadenylates (2-5As). These molecules activate latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. The three known members of this gene family are located in a cluster on chromosome 12. Alternatively, spliced transcript variants encoding different isoforms have been described. Diseases associated with OAS2 include Tick-Borne Encephalitis and Microphthalmia With Limb Anomalies.

    OAS2 の参考文献

    • Liao X, et al. (2020) 2', 5'-oligoadenylate synthetase 2 (oas2) inhibits zika virus replication through activation of type ι ifn signaling pathway. Viruses 12 (4): 418.
    • Koul A, et al. (2020) Impact of double-stranded rna characteristics on the activation of human 2'-5'-oligoadenylate synthetase 2 (oas2). Biochem Cell Biol 98 (1): 70-82.
    • Gu X, et al. (2016) Epigenetic regulation of oas2 shows disease-specific DNA methylation profiles at individual cpg sites. Sci Rep 6 32579.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.