NUP50 Antibodies, cDNA Clones Research Reagents

NUP50 (Nucleoporin 50, also known as NPAP60; NPAP60L), located on 22q13.31, is a Protein Coding gene. The gene produces a 50144 Da protein composed of 468 amino acids. NUP50 is the nucleolus-directed component of the nuclear pore complex with a role in protein export. NUP50 is a nucleoporin that binds directly to importin alpha. It is a mobile Nup with a pronounced presence both at the NPC and in the nucleoplasm that can move between these different localizations. NUP50 plays an essential role in the survival of primordial germ cells (PGCs) during embryonic development.

NUP50 Antibody (1)

    NUP50 cDNA Clone (16)

    NM_007172.3

    In expression vector

    BC060234.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NUP50 の背景知識

    Nup50 is a nucleoplasmically oriented component of the nuclear pore complex with a role in protein export. Npap60 (Nup50) is a nucleoporin that binds directly to importin alpha. In humans, there are two Npap60 isoforms: the long (Npap60L) and short (Npap60S) forms. Nucleoporin 50 kDa (NUP50), a component of the nuclear pore complex, is highly expressed in male germ cells. NUP50 plays an essential role in the survival of primordial germ cells (PGCs) during embryonic development. Nup50 is a mobile Nup with a pronounced presence both at the NPC and in the nucleoplasm that can move between these different localizations. Strikingly, the dynamic behavior of Nup50 in both locations is dependent on active transcription by RNA polymerase II and requires the N-terminal half of the protein, which contains importin α- and Nup153-binding domains.

    NUP50 の参考文献

    • Park E, et al. (2016) Nup50 is necessary for the survival of primordial germ cells in mouse embryos. Reproduction 151 (1): 51-58.
    • Ogawa Y, et al. (2010) Two isoforms of npap60 (nup50) differentially regulate nuclear protein import. Mol Biol Cell 21 (4): 630-638.
    • Buchwalter AL, et al. (2014) Nup50 is required for cell differentiation and exhibits transcription-dependent dynamics. Mol Biol Cell 25 (16): 2472-2484.

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