Numb Antibodies Research Reagents

NUMB (NUMB Endocytic Adaptor Protein) is a protein coding gene located on human chromosome 14q24.2-q24.3. NUMB is also known as S171, C14orf41 and c14_5527. The human NUMB gene encodes a 70804 Da protein containing 651 amino acids. The NUMB protein is ubiquitously expressed in lung, gall bladder and other tissues. Among its related pathways are Neuroscience and Signaling by GPCR. NUMB is related to beta-catenin binding and alpha-catenin binding. NUMBL is an important paralog of NUMB gene. NUMB is associated with some diseases, including Melanoma, Uveal and Maxillary Sinus Adenoid Cystic Carcinoma.

Numb Antibody (1)

    Numb の背景知識

    The protein Numb localizes to clathrin-coated vesicles and participates in the trafficking of transmembrane receptors. Numb is a protein whose asymmetric segregation during cell division determines cell fate and has numerous functions relevant to multiple fields of study, including developmental neurobiology and cancer biology. Numb serves as a key regulator of Notch and Sonic Hedgehog signaling and also modulates p53 protein levels. Numb functions as an oncosuppressor by inhibiting Notch signaling and stabilizing p53. This latter effect depends on the interaction of Numb with Mdm2, the E3 ligase that ubiquitinates p53 and commits it to degradation. In breast cancer (BC), loss of Numb results in a reduction of p53-mediated responses including sensitivity to genotoxic drugs and maintenance of homeostasis in the stem cell compartment.

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