NUDCD2 Antibodies, cDNA Clones Research Reagents

NUDCD2 (NudC Domain Containing 2, also known as NudCL2), located on 5q34, is a Protein Coding gene. The gene produces a 17676 Da protein composed of 157 amino acids. NUDCD2 is a new member of the NudC sub-family that plays an important role in the reformation and maintenance of nuclear integrity following mitosis. NUDCD2 is widely expressed in fat, prostate, and other tissues. Imbalances in the levels of NUDCD2 could be evaluated as a factor contributing to chromosomal instability in Head and Neck squamous cell carcinoma (HNSCC) through effects on the complex processes of mitosis and cell division.

NUDCD2 Antibody (1)

    NUDCD2 cDNA Clone (17)

    NM_145266.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001009621.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NUDCD2 の背景知識

    NUDCD2 (NudC Domain Containing 2) is a Protein Coding gene. The NUDCD2 gene, located on 5q34, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. NUDCD2 is a new member of the NudC sub-family that plays an important role in the reformation and maintenance of nuclear integrity following mitosis. An important paralog of this gene is NUDC. NUDCD2 is widely expressed in fat, prostate, and other tissues. NUDCD2 may regulate the LIS1/dynein pathway by stabilizing LIS1 with an Hsp90 chaperone. 239 organisms have orthologs with the human gene NUDCD2. Imbalances in the levels of NUDCD2 could be evaluated as a factor contributing to chromosomal instability in Head and Neck squamous cell carcinoma (HNSCC) through effects on the complex processes of mitosis and cell division.

    NUDCD2 の参考文献

    • Li M, et al. (2019) Nudc-like protein 2 restrains centriole amplification by stabilizing herc2. Cell Death Dis 10 (9): 628.
    • Lee OH, et al. (2011) Genome-wide yfp fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol Cell Proteomics 10 (2): M110.001628.
    • Galligan JT, et al. (2015) Proteomic analysis and identification of cellular interactors of the giant ubiquitin ligase herc2. J Proteome Res 14 (2): 953-966.

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