NUDCD2 (NudC Domain Containing 2) is a Protein Coding gene. The NUDCD2 gene, located on 5q34, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. NUDCD2 is a new member of the NudC sub-family that plays an important role in the reformation and maintenance of nuclear integrity following mitosis. An important paralog of this gene is NUDC. NUDCD2 is widely expressed in fat, prostate, and other tissues. NUDCD2 may regulate the LIS1/dynein pathway by stabilizing LIS1 with an Hsp90 chaperone. 239 organisms have orthologs with the human gene NUDCD2. Imbalances in the levels of NUDCD2 could be evaluated as a factor contributing to chromosomal instability in Head and Neck squamous cell carcinoma (HNSCC) through effects on the complex processes of mitosis and cell division.