NUCB2/Nucleobindin 2 Antibodies, cDNA Clones Research Reagents

NUCB2 (Nucleobindin 2, also known as NEFA; HEL-S-109), located on 11p15.1, is a Protein Coding gene. This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. The gene produces a 50223 Da protein composed of 420 amino acids. NUCB2 is a multifunctional protein containing several functional domains and is associated with a wide variety of biological processes such as food intake and energy homeostasis. NUCB2 plays a well-established role in homeostatic functions associated with food intake and stress integration.

NUCB2/Nucleobindin 2 Antibody (1)

    NUCB2/Nucleobindin 2 cDNA Clone (29)

    NM_005013.2

    In expression vector

    NM_001130479.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_004800444.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NUCB2/Nucleobindin 2 qPCR Primer (1)

    NUCB2/Nucleobindin 2 の背景知識

    Nucleobindin 2 (NUCB2) is a multifunctional protein containing several functional domains and is associated with a wide variety of biological processes such as food intake and energy homeostasis. Nesfatin-1/NucB2, an anorexigenic molecule, is expressed mainly in the hypothalamus, particularly in the supraoptic nucleus (SON) and the paraventricular nucleus (PVN). Nesfatin-1/NucB2 is also expressed in the subfornical organ (SFO). Because the SON and PVN are involved in body fluid regulation, nesfatin-1/NucB2 may be involved in dehydration-induced anorexia. NUCB2 plays a well-established role in homeostatic functions associated with food intake and stress integration. Nesfatin-1 is a hypothalamic anorexigenic peptide processed from Nucleobindin 2 (NUCB2). Central and peripheral administration of NUCB2/nesfatin-1 enhances glucose metabolism and insulin release. NUCB2/nesfatin-1 is also localized in pancreatic islets.

    NUCB2/Nucleobindin 2 の参考文献

    • Yoshimura M, et al. (2014) A role of nesfatin-1/nucb2 in dehydration-induced anorexia. Am J Physiol Regul Integr Comp Physiol 307 (2): R225-236.
    • Yang Y, et al. (2019) Islet β-cell-produced nucb2/nesfatin-1 maintains insulin secretion and glycemia along with suppressing ucp-2 in β-cells. J Physiol Sci 69 (5): 733-739.
    • Takagi K, et al. (2016) Nucleobindin 2 (nucb2) in human endometrial carcinoma: A potent prognostic factor associated with cell proliferation and migration. Endocr J 63 (3): 287-299.
    • Goebel-Stengel M, et al. (2016) Role of brain nucb2/nesfatin-1 in the stress-induced modulation of gastrointestinal functions. Curr Neuropharmacol 14 (8): 882-891.

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