NUB1 Antibodies, cDNA Clones Research Reagents

NUB1 (Negative Regulator Of Ubiquitin Like Proteins 1, also known as BS4; NUB1L; NYREN18), located on 7q36.1, is a Protein Coding gene. This gene encodes a protein that functions as a negative regulator of NEDD8. The gene produces a 70538 Da protein composed of 615 amino acids. It is an interferon-inducible protein and is predominantly localized in the nucleus. NUB1 negatively regulates the ubiquitin-like protein Nedd8 as well as glycosylated protein levels through proteasomal degradation. Diseases such as Leber Plus Disease and Brooke-Spiegler Syndrome are associated with NUB1.

NUB1 Antibody (1)

    NUB1 cDNA Clone (16)

    NM_001243351.1

    In expression vector

    NM_016736.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NUB1 qPCR Primer (1)

    NUB1 の背景知識

    The negative regulator of ubiquitin-like protein 1 (NUB1) is composed of 601 residues with a calculated 69.1-kDa molecular mass. It is an interferon-inducible protein and is predominantly localized in the nucleus. The NUB1 message is specifically expressed in adult human testis, ovary, heart, and skeletal muscle tissues and is developmentally down-regulated in mouse embryos. NEDD8 ultimate buster 1 (NUB1) is an interferon (IFN)-inducible protein that downregulates NEDD8 expression and its conjugation system. NUB1 negatively regulates the ubiquitin-like protein Nedd8 as well as neddylated proteins levels through proteasomal degradation. NUB1 interacts with a ubiquitin-like protein NEDD8 to target the NEDD8 monomer and neddylated proteins to the proteasome for degradation. Therefore, NUB1 is thought to be a potent down-regulator of the NEDD8 conjugation system.

    NUB1 の参考文献

    • Tanji K, et al. (2019) Phosphorylated nub1 distinguishes α-synuclein in lewy bodies from that in glial cytoplasmic inclusions in multiple system atrophy. Brain Pathol 29 (6): 803-812.
    • Tanji K, et al. (2005) Interaction of nub1 with the proteasome subunit s5a. Biochem Biophys Res Commun 337 (1): 116-120.
    • Kito K, et al. (2001) Nub1, a nedd8-interacting protein, is induced by interferon and down-regulates the nedd8 expression. J Biol Chem 276 (23): 20603-20609.
    • Bonacci T, et al. (2017) Regulation of nub1 activity through non-proteolytic mdm2-mediated ubiquitination. PLoS One 12 (1): e0169988.

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