NT5C3B Antibodies, cDNA Clones Research Reagents

NT5C3B (5'-Nucleotidase, Cytosolic IIIB, also known as NT5C3L; CN-IIIB), located on 17q21.2, is a Protein Coding gene. The gene produces a 34389 Da protein composed of 300 amino acids. NT5C3B is widely expressed in the testis, thyroid, and other tissues. NT5C3B specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. The related pathways of NT5C3B include metabolism and gene expression.

NT5C3B Antibody (1)

    NT5C3B cDNA Clone (16)

    NM_052935.4

    In expression vector

    XM_005584199.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NT5C3B の背景知識

    NT5C3B (5'-Nucleotidase, Cytosolic IIIB) is a Protein Coding gene. The NT5C3B gene, located on 17q21.2, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, fruit fly, mosquito, A.thaliana, rice, and frog. NT5C3B specifically hydrolyzes 7-methylguanosine monophosphate (m(7)GMP) to 7-methylguanosine and inorganic phosphate. The specific activity for m(7)GMP may protect cells against undesired salvage of m(7)GMP and its incorporation into nucleic acids. Also has a weak activity for CMP. UMP and purine nucleotides are poor substrates. NT5C3B is widely expressed in the testis, thyroid, and other tissues. Among its related pathways are Metabolism and Gene Expression. 215 organisms have orthologs with human gene NT5C3B.

    NT5C3B の参考文献

    • Monecke T, et al. (2014) Crystal structures of the novel cytosolic 5'-nucleotidase iiib explain its preference for m7gmp. PLoS One 9 (3): e90915.
    • Buschmann J, et al. (2013) Identification of drosophila and human 7-methyl gmp-specific nucleotidases. J Biol Chem 288 (4): 2441-2451.
    • Brieger A, et al. (2010) Cytoskeletal scaffolding proteins interact with lynch-syndrome associated mismatch repair protein mlh1. Proteomics 10 (18): 3343-3355.

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