NSL1 Antibodies, cDNA Clones Research Reagents

NSL1 (NSL1 Component Of MIS12 Kinetochore Complex, also known as DC8; MIS14; C1orf48), located on 1q32.3, is a Protein Coding gene. This gene encodes a protein with two coiled-coil domains that localize to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. There is a pseudogene of the 3' UTR region of this gene on chromosome X. The gene produces a 32162 Da protein composed of 281 amino acids. Diseases such as Arthrogryposis, Distal, Type 7, and Extraocular Retinoblastoma are associated with NSL1.

NSL1 Antibody (1)

    NSL1 cDNA Clone (15)

    NM_015471.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NSL1 の背景知識

    NSL1 (NSL1 Component Of MIS12 Kinetochore Complex) is a Protein Coding gene. The NSL1 gene, located on 1q32.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. This gene encodes a protein with two coiled-coil domains that localize to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. Diseases associated with NSL1 include Arthrogryposis, Distal, Type 7, and Extraocular Retinoblastoma. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.

    NSL1 の参考文献

    • Petrovic A, et al. (2010) The mis12 complex is a protein interaction hub for outer kinetochore assembly. J Cell Biol 190 (5): 835-852.
    • Liu XS, et al. (2012) Plk1 phosphorylates sgt1 at the kinetochores to promote timely kinetochore-microtubule attachment. Mol Cell Biol 32 (19): 4053-4067.
    • Davies AE, et al. (2010) Hsp90-sgt1 and skp1 target human mis12 complexes to ensure efficient formation of kinetochore-microtubule binding sites. J Cell Biol 189 (2): 261-274.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.