NSL1 (NSL1 Component Of MIS12 Kinetochore Complex) is a Protein Coding gene. The NSL1 gene, located on 1q32.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. This gene encodes a protein with two coiled-coil domains that localize to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. Multiple transcript variants encoding different isoforms have been found for this gene. There is a pseudogene of the 3' UTR region of this gene on chromosome X. Diseases associated with NSL1 include Arthrogryposis, Distal, Type 7, and Extraocular Retinoblastoma. Among its related pathways are Signaling by GPCR and Mitotic Prometaphase.