NRN1 Proteins, cDNA Clones Research Reagents

NRN1 (Neuritin 1, also known as NRN; dJ380B8.2), located on 6p25.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 15333 Da protein composed of 142 amino acids. This gene encodes a member of the neuritin family and is expressed in postmitotic-differentiating neurons of the developing nervous system and neuronal structures associated with plasticity in the adult. Diseases such as Megalencephalic Leukoencephalopathy With Subcortical Cysts 1 and Encephalomalacia are associated with NRN1. The related pathways of NRN1 include the Metabolism of proteins and Post-translational modification- synthesis of GPI-anchored proteins.

NRN1 Protein (1)

    NRN1 cDNA Clone (15)

    NM_001278710.1

    In expression vector

    NM_153529.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NRN1 qPCR Primer (1)

    NRN1 Lysate (1)

      NRN1 の背景知識

      Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF), and NT-3. Purified recombinant neuritin promotes neurite outgrowth and arborization in primary embryonic hippocampal and cortical cultures. Thus, neuritin is considered as a downstream effector of activity-induced neurite outgrowth. In clinical, neuritin levels in diabetes were reduced in both dorsal root ganglia and sciatic nerve of rats, and these deficits were reversed in vivo by treatment with NGF. This manipulation of neuritin levels in diabetes may provide a potential target for therapeutic intervention in the management of neuropathy.

      NRN1 の参考文献

      • Karamoysoyli E, et al. (2008) Neuritin mediates nerve growth factor-induced axonal regeneration and is deficient in experimental diabetic neuropathy. Diabetes. 57(1): 181-9.
      • Naeve GS, et al. (1997) Neuritin: A gene induced by neural activity and neurotrophins that promotes neuritogenesis. Proc Natl Acad Sci U S A. 94(6): 2648-2653.
      • Kojima N, et al. (2005) Expression of neuritin during liver maturation and regeneration. FEBS Lett. 579(21): 4562-6.

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