NRM/Nurim Antibodies, cDNA Clones Research Reagents

NRM (Nurim, also known as NRM29), located on 6p21.33, is a Protein Coding gene. The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane, where it is tightly associated with the nucleus. The gene produces a 29379 Da protein composed of 262 amino acids. NRM is a multispanning membrane protein without large hydrophilic domains that is very tightly associated with the nucleus. Unlike the known nuclear envelope (NE) membrane proteins, it is neither associated with nuclear pores nor targeted like lamin-associated membrane proteins.

NRM/Nurim Antibody (1)

    NRM/Nurim cDNA Clone (13)

    BC039865

    クローニングベクター cDNA 製品

    In lentiviral vector

    NRM/Nurim qPCR Primer (1)

    NRM/Nurim の背景知識

    NRM (Nurim) is a Protein Coding gene. The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane (INM), where it is tightly associated with the nucleus. Nurim is a multispanning membrane protein without large hydrophilic domains that is very tightly associated with the nucleus. Unlike the known nuclear envelope (NE) membrane proteins, it is neither associated with nuclear pores nor targeted like lamin-associated membrane proteins. This protein shares homology with isoprenylcysteine carboxy methyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Nurim lacks an N-terminal domain characteristic of other INM proteins examined to date and may represent a class of proteins that localize to the INM by a distinct mechanism.

    NRM/Nurim の参考文献

    • Rolls MM, et al. (1999) A visual screen of a gfp-fusion library identifies a new type of nuclear envelope membrane protein. J Cell Biol 146 (1): 29-44.
    • Hofemeister H, et al. (2005) Analysis of the localization and topology of nurim, a polytopic protein tightly associated with the inner nuclear membrane. J Biol Chem 280 (4): 2512-2521.
    • Chen H, et al. (2012) The integral nuclear membrane protein nurim plays a role in the suppression of apoptosis. Curr Mol Med 12 (10): 1372-1382.

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