NRM (Nurim) is a Protein Coding gene. The protein encoded by this gene contains transmembrane domains and resides within the inner nuclear membrane (INM), where it is tightly associated with the nucleus. Nurim is a multispanning membrane protein without large hydrophilic domains that is very tightly associated with the nucleus. Unlike the known nuclear envelope (NE) membrane proteins, it is neither associated with nuclear pores nor targeted like lamin-associated membrane proteins. This protein shares homology with isoprenylcysteine carboxy methyltransferase enzymes. Alternative splicing results in multiple transcript variants that encode different protein isoforms. Nurim lacks an N-terminal domain characteristic of other INM proteins examined to date and may represent a class of proteins that localize to the INM by a distinct mechanism.