NRG4 Proteins, Antibodies, cDNA Clones Research Reagents

NRG4 (Neuregulin 4, also known as HRG4), located on 15q24.2, is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, and chicken. The gene produces a 12722 Da protein composed of 115 amino acids. The neuregulins, including NRG4, activate type-1 growth factor receptors to initiating cell-to-cell signaling through tyrosine phosphorylation. NRG4 is a member of the neuregulin protein family and is ubiquitously expressed in the prostate, skin, and other tissue. The related pathways of NRG4 include RET signaling and Signaling by GPCR.

NRG4 Protein (1)

    NRG4 Antibody (3)

      NRG4 cDNA Clone (13)

      BC017568

      クローニングベクター cDNA 製品

      In lentiviral vector

      NRG4 qPCR Primer (1)

      NRG4 の背景知識

      NRG4 (neuregulin 4) is a member of the neuregulin protein family. The neuregulins consist of four structurally-related proteins that are part of the EGF family of proteins. It has been shown that these proteins have diverse functions in the development of the nervous system and play multiple essential roles in vertebrate embryogenesis including cardiac development, Schwann cell, and oligodendrocyte differentiation, some aspects of neuronal development, as well as the formation of neuromuscular synapses. NRG4 contains 1 EGF-like domain. It activates type-1 growth factor receptors to initiating cell-to-cell signaling through tyrosine phosphorylation. NRG4 is a low-affinity ligand for the ERBB4 tyrosine kinase receptor. It concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. However, it does not bind to the ERBB1, ERBB2, and ERBB3 receptors.

      NRG4 の参考文献

      • Strausberg RL, et al. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proc Nat Acad Sci. 99(26):16899-903.
      • Harari D, et al. (1999) Neuregulin-4: a novel growth factor that acts through the ErbB-4 receptor tyrosine kinase. Oncogene. 18(17):2681-9.
      • Memon AA, et al. (2004) Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients. Br J Cancer. 91(12) 2034-41.

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