NQO2 Antibodies, cDNA Clones Research Reagents

NQO2 (N-Ribosyldihydronicotinamide: Quinone Reductase 2, also known as QR2; DHQV; DIA6; NMOR2), located on 6p25.2, is a Protein Coding gene. This gene encodes a member of the thioredoxin family of enzymes. The gene produces a 25919 Da protein composed of 231 amino acids. The human NQO2 cDNA and protein are 54 and 49% similar to the human liver cytosolic NQO1 cDNA and protein. Disruption of the NQO2 gene in mice leads to γ radiation-induced myeloproliferative diseases. Diseases such as Breast Cancer and Alcoholic Pancreatitis are associated with NQO2.

NQO2 Antibody (1)

    NQO2 cDNA Clone (30)

    BC006096

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001163241.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NQO2 qPCR Primer (1)

    NQO2 の背景知識

    NQO2 is a 231 amino acid protein (25956 MW) that is 43 amino acids shorter than NQO1 at its carboxy-terminus. The human NQO2 cDNA and protein are 54 and 49% similar to the human liver cytosolic NQO1 cDNA and protein. NRH: quinone oxidoreductase 2 (NQO2) is a cytosolic and ubiquitously expressed flavoprotein that catalyzes the two-electron reduction of quinone to hydroquinones. NQO2 catalyzes the metabolic reduction of quinones and provides protection against myelogenous hyperplasia and chemical carcinogenesis. Disruption of the NQO2 gene in mice leads to γ radiation-induced myeloproliferative diseases. NQO2 is involved in ROS generation and subsequent cytotoxicity in oocytes and its inhibition can restore oocyte maturation and embryo development, suggesting NQO2 as a pharmacological target for infertility cure.

    NQO2 の参考文献

    • Xu J, et al. (2013) Nrh:Quinone oxidoreductase 2 (nqo2) protein competes with the 20 s proteasome to stabilize transcription factor ccaat enhancer-binding protein α (c/ebpα), leading to protection against γ radiation-induced myeloproliferative disease. J Biol Chem 288 (48): 34799-34808.
    • Long DJ, 2nd, et al. (2000) Nrh:Quinone oxidoreductase2 (nqo2). Chem Biol Interact 129 (1-2): 99-112.
    • Chen D, et al. (2017) Nqo2 inhibition relieves reactive oxygen species effects on mouse oocyte meiotic maturation and embryo development. Biol Reprod 97 (4): 598-611.

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