NQO1 Proteins, Antibodies, cDNA Clones Research Reagents

NQO1 (NAD(P)H Quinone Dehydrogenase 1, also known as DTD; QR1; DHQU; DIA4; NMOR1; NMORI), located on 16q22.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 30868 Da protein composed of 274 amino acids. NQO1 is a flavoprotein that catalyzes the 2-electron reduction of various quinones and redox dyes, such as phyloquinone and the vitamin K menadione. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species.

NQO1 Protein (1)

    NQO1 Antibody (2)

      NQO1 cDNA Clone (32)

      NM_000903.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008706.5

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_017000.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NQO1 qPCR Primer (1)

      NQO1 の背景知識

      NQO1 gene is a member of the NAD(P)H dehydrogenase (quinone) family and encodes a cytoplasmic 2-electron reductase. NQO1 forms homodimers and reduces quinones to hydroquinones. NQO1's enzymatic activity prevents the one-electron reduction of quinones that results in the production of radical species. Mutations in the NQO1 gene have been associated with tardive dyskinesia (TD), an increased risk of hematotoxicity after exposure to benzene, and susceptibility to various forms of cancer. Altered expression of NQO1 has been seen in many tumors and is also associated with Alzheimer's disease (AD). Alternate transcriptional splice variants, encoding different isoforms, have been characterized. Recent pharmacological research suggests the feasibility of genotype-directed redox chemotherapeutic intervention targeting NQO1 breast cancer, a common missense genotype encoding a functionally impaired NQO1 protein.

      NQO1 の参考文献

      • Ross David. et al., 2002, J Biol Chem. 277 (16): 14060-7.
      • Cabello CM. et al., 2010, Free Radic Res. 45 (3): 276-92.
      • Adesnik M. et al., 1988, J Biol Chem. 263 (27): 13572-8.

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