NPC2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

NPC2 (NPC Intracellular Cholesterol Transporter 2, also known as HE1; EDDM1), located on 14q24.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, and frog. The gene produces a 16570 Da protein composed of 151 amino acids. This gene encodes a protein containing a lipid recognition domain. NPC2 is ubiquitously expressed in the lung, thyroid, and other tissues. Diseases such as Niemann-Pick Disease, Type C2, and Niemann-Pick Disease, Type C1 are associated with NPC2. The related pathways of NPC2 include Lipoprotein metabolism and Lysosome.

NPC2 Protein (3)

    NPC2 Antibody (12)

      NPC2 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      NPC2 cDNA Clone (39)

      BC002532

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_023409.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_173118.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NPC2 Lysate (3)

        NPC2 の背景知識

        Niemann-Pick Type C2 (NPC2) plays an important role in the regulation of intracellular cholesterol homeostasis via direct binding with free cholesterol. NPC2 is an intralysosomal protein that binds cholesterol in vitro. NPC2 is a small lysosomal glycoprotein that binds cholesterol with submicromolar affinity. Deficiency in NPC2 is the cause of Niemann-Pick type C2 disease, a fatal neurovisceral disorder characterized by the accumulation of cholesterol in lysosomes. Niemann-Pick disease, type C2 (NPC2) protein is one of the most abundant components of the epididymal fluid and contains a functional cholesterol-binding site that can transfer cholesterol between membranes, it has been suggested for years that NPC2 could be involved in the regulation of cholesterol levels in spermatozoa during epididymal maturation.

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