NOV/CCN3 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

All NOV/CCN3 reagents are produced in house and quality controlled, including 6 NOV/CCN3 Antibody, 1 NOV/CCN3 ELISA, 52 NOV/CCN3 Gene, 3 NOV/CCN3 Lysate, 3 NOV/CCN3 Protein, 2 NOV/CCN3 qPCR. All NOV/CCN3 reagents are ready to use.

NOV/CCN3 Protein (3)

    NOV/CCN3 Antibody (6)

      NOV/CCN3 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(1)

      NOV/CCN3 cDNA Clone (52)

      NM_002514.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_010930.4

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_532317.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_001097136.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NOV/CCN3 Lysate (3)

        NOV/CCN3 の背景知識

        Protein NOV homolog, also known as Nephroblastoma-overexpressed gene protein homolog, NOV, and CCN3, is a putative ligand for integrin receptors, is tightly associated with the extracellular matrix and mediates diverse cellular functions, including cell adhesion and proliferation. CCN3 has been shown to negatively regulate growth although it promotes migration in a cell type-specific manner. This secreted protein belongs to the CCN family, and its expression was observed in a broad variety of tissues from the early stage of development , and altered expression of CCN3 has been observed in a variety of tumors, including hepatocellular carcinomas, Wilm's tumors, Ewing's sarcomas, gliomas, rhabdomyosarcomas, and adrenocortical carcinomas. Mature CCN3 protein has five distinct modules and truncated protein variants with altered function are found in many cancers. CCN3 acts through the core stem cell signalling pathways including Notch and Bone Morphogenic Protein, connecting CCN3 with the modulation of self-renewal and maturation of a number of cell lineages including hematopoietic, osteogenic and chondrogenic. CCN3 may affect the extracellular environment of the niche for hematopoietic stem cells. CCN3 has emerged as a key player in stem cell regulation, hematopoiesis and a crucial component within the bone marrow microenvironment.

        NOV/CCN3 の参考文献

        • Manara MC, et al. (2002) The expression of ccn3(nov) gene in musculoskeletal tumors. Am J Pathol. 160(3): 849-59.
        • Lin CG, et al. (2003) CCN3 (NOV) is a novel angiogenic regulator of the CCN protein family. J Biol Chem. 278(26): 24200-8.
        • Vallacchi V, et al. (2009) CCN3/nephroblastoma overexpressed matricellular protein regulates integrin expression, adhesion, and dissemination in melanoma. Cancer Res. 68(3): 715-23.
        • Sin WC, et al. (2009) Matricellular protein CCN3 (NOV) regulates actin cytoskeleton reorganization. J Biol Chem. 284(43): 29935-44.
        • McCallum L, et al. (2009) CCN3--a key regulator of the hematopoietic compartment. Blood Rev. 23(2): 79-85.

        Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.