NOS1AP Antibodies, cDNA Clones Research Reagents

NOS1AP (Nitric Oxide Synthase 1 Adaptor Protein, also known as CAPON; 6330408P19Rik), located on 1q23.3, is a Protein Coding gene. This gene encodes a cytosolic protein that binds to the signaling molecule, neuronal nitric oxide synthase (nNOS). The gene produces a 56150 Da protein composed of 506 amino acids. Structurally, NOS1AP consists of a phosphotyrosine-binding (PTB) domain at its N-terminal and a PDZ (PSD-95/discs-large/ZO-1) ligand motif at its C-terminal. Diseases such as Long Qt Syndrome 1 and Long Qt Syndrome are associated with NOS1AP.

NOS1AP Antibody (1)

    NOS1AP cDNA Clone (15)

    BC112295

    クローニングベクター cDNA 製品

    In lentiviral vector

    NOS1AP qPCR Primer (1)

    NOS1AP の背景知識

    Nitric Oxide Synthase 1 Adaptor Protein (NOS1AP, previously named CAPON) was firstly identified in the rat brain in 1998, and its SNP rs12742393 was associated with type 2 diabetes (T2D). Structurally, NOS1AP consists of a phosphotyrosine-binding (PTB) domain at its N-terminal and a PDZ (PSD-95/discs-large/ZO-1) ligand motif at its C-terminal. The PTB domain of NOS1AP mediates the interactions with Dexras1, scribble, and synapsins. The PDZ ligand motif of NOS1AP binds to the PDZ domain of NOS1, the enzyme responsible for nitric oxide synthesis in the nervous system. NOS1AP is implicated in Dexras1 activation, neuronal nitric oxide production, Hippo pathway signaling, and dendritic development through the association with these important partners. An increasing body of evidence is pointing to the significant roles of NOS1AP in excitotoxic neuronal damage, traumatic nervous system injury, bipolar disorder, and schizophrenia.

    NOS1AP の参考文献

    • Wang J, et al. (2016) Research progress in nos1ap in neurological and psychiatric diseases. Brain Res Bull 125 99-105.
    • Mu K, et al. (2019) Hepatic nitric oxide synthase 1 adaptor protein regulates glucose homeostasis and hepatic insulin sensitivity in obese mice depending on its pdz binding domain. EBioMedicine 47 352-364.
    • Clattenburg L, et al. (2015) Nos1ap functionally associates with yap to regulate hippo signaling. Mol Cell Biol 35 (13): 2265-2277.

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