NOLC1 Antibodies, cDNA Clones Research Reagents

NOLC1 (Nucleolar And Coiled-Body Phosphoprotein 1, also known as P130; Srp40; NOPP130; NOPP140; NS5ATP13), located on 10q24.32, is a Protein Coding gene. The gene produces a 73603 Da protein composed of 699 amino acids. NOLC1 is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). DNA methylation is a key mechanism of silenced NOLC1 expression in human hepatocellular carcinoma cells. Diseases such as Lissencephaly and Treacher Collins Syndrome 1 are associated with NOLC1.

NOLC1 Antibody (1)

    NOLC1 cDNA Clone (17)

    NM_001284389.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    XM_006231560.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NOLC1 qPCR Primer (1)

    NOLC1 の背景知識

    Nucleolar and coiled-body phosphoprotein 1 (NOLC1) is a phosphoprotein that transiently associates with the mature nucleolar H/ACA and C/D box small nucleolar ribonucleoproteins (snoRNPs). NOLC1 plays an essential role in the synthesis of rRNA and the biosynthesis of ribosomes. NOLC1 is responsible for the nucleolus construction and rRNA synthesis interacted with TRF2 and mediated the shuttle of TRF2 between the nucleolus and nucleus. Studies suggest that NOLC1 is crucial for normal cell growth, and plays a role in the regulation of tumorigenesis of nasopharyngeal carcinoma (NPC) and demonstrate that both NOLC1 and tumor protein 53 work synergistically to activate the MDM2 promoter in NPC cells. DNA methylation is a key mechanism of silenced NOLC1 expression in human hepatocellular carcinoma cells, and NOLC1 gene hypermethylation of the four CpG dinucleotides is a potential biomarker for hepatocellular carcinoma.

    NOLC1 の参考文献

    • Yuan F, et al. (2018) Nucleolar trf2 attenuated nucleolus stress-induced hcc cell-cycle arrest by altering rrna synthesis. Cell Death Dis 9 (5): 518.
    • Gao X, et al. (2011) Identification of nucleolar and coiled-body phosphoprotein 1 (nolc1) minimal promoter regulated by nf-κb and creb. BMB Rep 44 (1): 70-75.
    • Duan X, et al. (2013) Methylation of nucleolar and coiled-body phosphoprotein 1 is associated with the mechanism of tumorigenesis in hepatocellular carcinoma. Oncol Rep 30 (5): 2220-2228.

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