NMNAT1 Proteins, Antibodies, cDNA Clones Research Reagents

NMNAT1 (Nicotinamide Nucleotide Adenylyltransferase 1, also known as LCA9; NMNAT; PNAT1), located on 1p36.22, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, S.cerevisiae, K.lactis, E.gossypii, S.pombe, and frog. The gene produces a 31932 Da protein composed of 279 amino acids. This gene encodes an enzyme that catalyzes a key step in the biosynthesis of nicotinamide adenine dinucleotide (NAD). Diseases such as Leber Congenital Amaurosis 9 and Diarrhea are associated with NMNAT1. The related pathways of NMNAT1 include the superpathway of tryptophan utilization and the Metabolism of water-soluble vitamins and cofactors.

NMNAT1 Protein (1)

    NMNAT1 Antibody (1)

      NMNAT1 cDNA Clone (29)

      NM_022787.3

      クローニングベクター cDNA 製品

      In lentiviral vector

      NMNAT1 qPCR Primer (1)

      NMNAT1 Lysate (1)

        NMNAT1 の背景知識

        NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enzyme is vital for NAD biosynthesis, catalyzing the condensation of nicotinamide mononucleotide (NMN) or nicotinic acid mononucleotide (NaMN) with the AMP moiety of ATP to form NAD or NaAD.

        NMNAT1 の参考文献

        • Sugano S. et al., 1994, Gene. 138 (1-2): 171-4.
        • Saccucci F. et al., 2001, J Biol Chem. 276 (1): 406-12.
        • Hennig K. et al., 2001, FEBS Lett. 492 (1-2): 95-100.

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