NME1 Proteins, Antibodies, cDNA Clones Research Reagents

NME1 (NME/NM23 Nucleoside Diphosphate Kinase 1, also known as NB; AWD; NBS; GAAD; NDKA; NM23; NDPKA; NDPK-A; NM23-H1), located on 17q21.33, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, A.thaliana, and rice. The gene produces a 17149 Da protein composed of 152 amino acids. This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Diseases such as Anal Canal Carcinoma and Larynx Cancer are associated with NME1. The related pathways of NME1 include Zidovudine Pathway, Pharmacokinetics/Pharmacodynamics, and superpathway of pyrimidine deoxyribonucleotides de novo biosynthesis.

NME1 Protein (1)

    NME1 Antibody (11)

      NME1 cDNA Clone (45)

      NM_000269.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008704.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_005624340.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NME1 の背景知識

      NME1, also known as Nucleoside Diphosphate Kinase A (NDK-A), or NM23-H1, belongs to the NDK family. NM23-H1 is known to have a metastasis suppressive activity in many tumor cells. Recent studies have shown that the interacting proteins with NM23-H1 which mediate cell proliferation, may act as modulators of the metastasis suppressor activity. The interacting proteins with NM23-H1 can be classified into 3 groups. The first group of proteins can be classified as upstream kinases of NM23-H1 such as CKI and Aurora-A/STK15. The second group of proteins acts as downstream effectors for the regulation of specific gene transcriptions, GTP-binding protein functions, and signal transduction in the Erk signal cascade. The third group of proteins can be classified as bi-directionally influencing binding partners of NM23-H1. As a result, the interactions with NM23-H1 and binding partners have implications in the biochemical characterization involved in metastasis and tumorigenesis. NDKA is increased in human postmortem cerebrospinal fluid (CSF), a model of global brain insult, suggesting that measurement in CSF and, more importantly, in plasma may be useful as a biomarker of stroke. Additionally, NM23-H1 significantly reduces metastasis without effects on primary tumor size and was the first discovered metastasis suppressor gene.

      NME1 の参考文献

      • Allard L, et al. (2005) PARK7 and nucleoside diphosphate kinase A as plasma markers for the early diagnosis of stroke. Clin Chem. 51(11): 2043-51.
      • Steeg PS, et al. (2008) Clinical-translational approaches to the Nm23-H1 metastasis suppressor. Clin Cancer Res. 14(16): 5006-12.
      • Kim HD, et al. (2009) Regulators affecting the metastasis suppressor activity of Nm23-H1. Mol Cell Biochem. 329(1-2): 167-73.

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