NLGN4X Proteins, Antibodies, cDNA Clones Research Reagents

NLGN4X (Neuroligin 4 X-Linked, also known as HLNX; HNL4X; NLGN4; ASPGX2; AUTSX2), located on Xp22.32-p22.31, is conserved in chimpanzee, zebrafish, M.oryzae, and N.crassa. The gene produces a 91915 Da protein composed of 816 amino acids. This gene encodes a member of the type-B carboxylesterase/lipase protein family. NLGN4X is broadly expressed in the brain, ovary, and other tissue. Diseases such as Autism X-Linked 2 and Asperger Syndrome, X-Linked 2 are associated with NLGN4X. The related pathways of NLGN4X include Cell adhesion molecules (CAMs) and Protein-protein interactions at synapses.

NLGN4X Protein (2)

    NLGN4X Antibody (2)

      NLGN4X cDNA Clone (13)

      NM_020742.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NLGN4X qPCR Primer (1)

      NLGN4X Lysate (2)

        NLGN4X の背景知識

        NLGN4X (Neuroligin 4 X-Linked) is a Protein Coding gene. This gene encodes a member of the type-B carboxylesterase/lipase protein family. The encoded protein belongs to a family of neuronal cell surface proteins. NLGN4X interacts with discs large homolog 4 (DLG4). It is broadly expressed in the brain, ovary, and other tissues. Genetic mutations in NLGN4X, including point mutations and copy number variants (CNVs), have been associated with susceptibility to autism spectrum disorders (ASDs). Pathogenic mutations in the NLGN4X gene in ASDs and/or mental retardation (MR) are rare. Based on in vitro models, NLGN4X knockdown directly impacts the neurodevelopmental process during the formation of neurons and their connections.

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