NLE1 (Notchless Homolog 1) is a Protein Coding gene. The NLE1 gene, located on 17q12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. NLE1 is a member of the large WD40-repeat protein family and is thought to signal via the canonical NOTCH pathway in vertebrates. NLE1 plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. In the mouse, Notchless homolog 1 (Drosophila) (Nle1) is instrumental for the survival of cells of the inner cell mass upon implantation. Diseases associated with NLE1 include Heart Block, Congenital, and Meningoencephalitis.