NLE1 Antibodies, cDNA Clones Research Reagents

NLE1 (Notchless Homolog 1, also known as NLE), located on 17q12, is a Protein Coding gene. The gene produces a 53320 Da protein composed of 485 amino acids. NLE1 is a member of the large WD40-repeat protein family and is thought to signal via the canonical NOTCH pathway in vertebrates. In the mouse, Notchless homolog 1 (Drosophila) (Nle1) is instrumental for the survival of cells of the inner cell mass upon implantation. Diseases such as Heart Block, Congenital, and Meningoencephalitis are associated with NLE1.

NLE1 Antibody (1)

    NLE1 cDNA Clone (30)

    NM_001014445.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_145431.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NLE1 の背景知識

    NLE1 (Notchless Homolog 1) is a Protein Coding gene. The NLE1 gene, located on 17q12, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, rice, and frog. NLE1 is a member of the large WD40-repeat protein family and is thought to signal via the canonical NOTCH pathway in vertebrates. NLE1 plays a role in regulating Notch activity. Plays a role in regulating the expression of CDKN1A and several members of the Wnt pathway, probably via its effects on Notch activity. In the mouse, Notchless homolog 1 (Drosophila) (Nle1) is instrumental for the survival of cells of the inner cell mass upon implantation. Diseases associated with NLE1 include Heart Block, Congenital, and Meningoencephalitis.

    NLE1 の参考文献

    • Romes EM, et al. (2016) The crystal structure of the ubiquitin-like domain of ribosome assembly factor ytm1 and characterization of its interaction with the aaa-atpase midasin. J Biol Chem 291 (2): 882-893.
    • Lossie AC, et al. (2012) Enu mutagenesis reveals that notchless homolog 1 (drosophila) affects cdkn1a and several members of the wnt pathway during murine pre-implantation development. BMC Genet 13 106.
    • Beck-Cormier S, et al. (2014) Notchless is required for axial skeleton formation in mice. PLoS One 9 (5): e98507.

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