NKX2.5 cDNA Clones Research Reagents

NKX2-5 (NK2 Homeobox 5, also known as CSX; CSX1; VSD3; CHNG5; HLHS2; NKX2E; NKX2.5; NKX4-1), located on 5q35.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 34918 Da protein composed of 324 amino acids. This gene encodes a homeobox-containing transcription factor. Diseases such as Atrial Septal Defect 7 With Or Without Atrioventricular Conduction Defects and Ventricular Septal Defect 3 are associated with NKX2-5. The related pathways of NKX2-5 include Heart Development and Mesenchymal Stem Cells and Lineage-specific Markers.

NKX2.5 cDNA Clone (15)

NM_004387.3

クローニングベクター cDNA 製品

In lentiviral vector

NKX2.5 qPCR Primer (1)

NKX2.5 の背景知識

NKX2-5 (NK2 Homeobox 5) is a Protein Coding gene. This gene encodes a homeobox-containing transcription factor. This transcription factor functions in heart formation and development. It belongs to the NK-2 homeobox family. NKX2-5 is a homeodomain-containing transcription factor implied in both heart and thyroid development. Diseases associated with NKX2-5 include Atrial Septal Defect 7 With Or Without Atrioventricular Conduction Defects and Ventricular Septal Defect 3. Heterozygous mutations in NKX2-5 in both the human and mice result in congenital heart defects (CHDs). Numerous mutations in NKX2-5 have been reported in individuals with congenital heart disease (CHD). Mutations in this gene can also cause congenital hypothyroidism non-goitrous type 5, a non-autoimmune condition.

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