NKp44/NCR2 Proteins, cDNA Clones Research Reagents

NCR2 (Natural Cytotoxicity Triggering Receptor 2, also known as LY95; CD336; NKP44; NK-p44; dJ149M18.1), located on 6p21.1, is a Protein Coding gene. The gene produces a 30677 Da protein composed of 276 amino acids. NCR2 is a type I transmembrane protein with a 21-amino acid leader sequence, a 169-amino acid extracellular region, a 23-amino acid transmembrane protein, and a 63-amino acid cytoplasmic tail. The related pathways of NCR2 include the Immune response Role of DAP12 receptors in NK cells and Hematopoietic Stem Cells and Lineage-specific Markers.

NKp44/NCR2 Protein (2)

    NKp44/NCR2 cDNA Clone (13)


    クローニングベクター cDNA 製品

    In lentiviral vector

    NKp44/NCR2 qPCR Primer (1)

    NKp44/NCR2 Lysate (1)

      NKp44/NCR2 の背景知識

      Natural cytotoxicity triggering receptor 2 (NCR2), also known as Natural killer cell p44-related protein (NKp44), or CD336, is a member of the natural cytotoxicity receptor (NCR) family, which composed of one Ig-like extracellular domain, a transmembrane segment, and a cytoplasmic domain. It is a novel transmembrane glycoprotein belonging to the Immunoglobulin superfamily characterized by a single extracellular V-type domain. The cytoplasmic domain of NKp44 also contains a sequence that matches the immunoreceptor tyrosine-based inhibitory motif (ITIM) consensus. This Cytotoxicity-activating receptor may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. NKp44 is selectively expressed by IL-2-activated NK cells and may contribute to the increased efficiency of activated NK cells to mediate tumor cell lysis. Tumor cell recognition of the mutated NKp44 proteins was significantly reduced and correlated with their lower recognition of heparin.

      NKp44/NCR2 の参考文献

      • Vitale M, et al. (1998) NKp44, a novel triggering surface molecule specifically expressed by activated natural killer cells, is involved in non-major histocompatibility complex-restricted tumor cell lysis. J Exp Med. 187(12): 2065-72.
      • Cantoni C, et al. (1999) NKp44, a triggering receptor involved in tumor cell lysis by activated human natural killer cells, is a novel member of the immunoglobulin superfamily. J Exp Med. 189: 787-96.
      • Cantoni C, et al. (2003) The three-dimensional structure of the human NK cell receptor NKp44, a triggering partner in natural cytotoxicity. Structure. 11(6): 725-34.
      • Campbell KS, et al. (2004) NKp44 triggers NK cell activation through DAP12 association that is not influenced by a putative cytoplasmic inhibitory sequence. J Immunol. 172(2): 899-906.
      • Hershkovitz O, et al. (2007) Characterization of the recognition of tumor cells by the natural cytotoxicity receptor, NKp44. Biochemistry. 46(25): 7426-36.

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