NKD2 Antibodies, cDNA Clones Research Reagents

NKD2 (NKD Inhibitor Of WNT Signaling Pathway 2, also known as Naked2), located on 5p15.33, is a Protein Coding gene. This gene encodes a member of a family of proteins that function as negative regulators of Wnt receptor signaling through interaction with Dishevelled family members. The gene produces a 50055 Da protein composed of 451 amino acids. NKD2 plays a vital role in cell homeostasis and the prevention of tumorigenesis. The related pathways of NKD2 include S45 mutants of beta-catenin arent phosphorylated and Wnt signaling pathway.

NKD2 Antibody (1)

    NKD2 cDNA Clone (15)

    BC012176

    クローニングベクター cDNA 製品

    In lentiviral vector

    NKD2 qPCR Primer (1)

    NKD2 の背景知識

    Naked cuticle homolog2 (NKD2) is located in chromosome 5p15.3, which is a frequent loss of heterozygosity in human colorectal and gastric cancers. Naked2 (NKD2), one member of the Naked family, has been shown to negatively regulate the Wnt/β-catenin signaling pathway. It has been recognized that NKD2 plays a vital role in cell homeostasis and the prevention of tumorigenesis. NKD2 inhibits tumor growth and metastasis in OS by suppressing Wnt signaling. Naked cuticle homolog 2 (NKD2) was found to be frequently methylated in human breast and gastric cancers. NKD2 is frequently methylated in human esophageal cancer, and the expression of NKD2 is regulated by promoter region methylation. NKD2 suppresses esophageal cancer progression by inhibiting Wnt signaling both in vitro and in vivo.

    NKD2 の参考文献

    • Jia Y, et al. (2015) Silencing nkd2 by promoter region hypermethylation promotes gastric cancer invasion and metastasis by up-regulating sox18 in human gastric cancer. Oncotarget 6 (32): 33470-33485.
    • Cui Z, et al. (2016) Up-regulation of corticocerebral nkd2 in lipopolysaccharide-induced neuroinflammation. Cell Mol Neurobiol 36 (1): 47-55.
    • Cao B, et al. (2016) Silencing nkd2 by promoter region hypermethylation promotes esophageal cancer progression by activating wnt signaling. J Thorac Oncol 11 (11): 1912-1926.

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