Ninjurin-1 Proteins, cDNA Clones Research Reagents

NINJ1 (Ninjurin 1, also known as NIN1; NINJURIN), located on 9q22.31, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 16345 Da protein composed of 152 amino acids. The NINJ1 gene encodes ninjurin, a protein that is upregulated after nerve injury both in dorsal root ganglion neurons and in Schwann cells. It is ubiquitously expressed in bone marrow, placenta, and other tissues. Diseases such as Hereditary Sensory Neuropathy and Non-Functioning Pancreatic Endocrine Tumor are associated with NINJ1.

Ninjurin-1 Protein (1)

    Ninjurin-1 cDNA Clone (39)

    NM_004148.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_013610.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_012867.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    Ninjurin-1 qPCR Primer (1)

    Ninjurin-1 Lysate (1)

      Ninjurin-1 の背景知識

      Ninjurin-1, also known as NINJ1, is a member of the Ninjurin family of transmembrane (TM) proteins. It is expressed in CD19(+) CD10(+) B-cell progenitor cells and higher levels in B-lineage acute lymphoblastic leukemia cells. Ninjurin-1 is expressed also in some other adult and embryonic tissues, predominantly in epithelial cells. Its expression is upregulated after axotomy in neurons and Schwann cells surrounding the distal nerve segment. Upregulated expression of ninjurin-1 has been identified as a marker of minimal residual disease in B-lineage acute lymphoblastic leukemia. It mediates homophilic adhesion and promotes neurite extension of dorsal root ganglion neurons in vitro. Ninjurin-1 has been found to show a high expression level in the liver tissue of patients with hepatocellular carcinoma, and this seems to be associated with cases of cirrhosis and chronic viral hepatitis. It has been reported that NINJURIN increases p21 expression and induces cellular senescence in human hepatoma cells.

      Ninjurin-1 の参考文献

      • Cardoso CC, et al. (2007) Ninjurin 1 asp110ala single nucleotide polymorphism is associated with protection in leprosy nerve damage. J Neuroimmunol. 190 (1-2): 131-8.
      • Ifergan I, et al. (2011) Role of Ninjurin-1 in the migration of myeloid cells to central nervous system inflammatory lesions. Ann Neurol. 70 (5): 751-63.
      • Toyama T, et al. (2005) Ninjurin1 increases p21 expression and induces cellular senescence in human hepatoma cells. J Hepatol. 41 (4): 637-43.

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