NFATC3 Antibodies, cDNA Clones Research Reagents

NFATC3 (Nuclear Factor Of Activated T Cells 3, also known as NFAT4; NFATX; NF-AT4c), located on 16q22.1, is a Protein Coding gene. The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. The gene produces a 115594 Da protein composed of 1075 amino acids. NFATc3, which is a Ca(2+)-dependent transcription factor, has been recently linked to smooth muscle phenotypic maintenance through the regulation of the expression of alpha-actin. Diseases such as Crouzon Syndrome With Acanthosis Nigricans and Leukostasis are associated with NFATC3.

NFATC3 Antibody (1)

    NFATC3 cDNA Clone (15)

    BC001050

    クローニングベクター cDNA 製品

    In lentiviral vector

    NFATC3 qPCR Primer (1)

    NFATC3 の背景知識

    NFATc3 (nuclear factor of activated T cells isoform c3), which is a Ca(2+)-dependent transcription factor, has been recently linked to smooth muscle phenotypic maintenance through the regulation of the expression of alpha-actin. The calcium-dependent transcription factor NFATc3, which is a member of the nuclear factor of activated T cells (NFAT) family of transcription factors, is critical for embryonic vascular development and differentiation. NFATc3 is participated in inflammation and cancer and plays a role in maintaining the pancreatic β-cell compensatory growth and gene expression in response to obesity. The transcription factor NFATC3 specifically binds to IRF7 and enhances IRF7-mediated IFN production. Furthermore, knockout of NFATC3 greatly reduced the CpG DNA-induced nuclear translocation of IRF7, which resulted in impaired type 1 IFN production in vitro and in vivo.

    NFATC3 の参考文献

    • Lee SH, et al. (2019) Nfatc3 plays an oncogenic role in oral/oropharyngeal squamous cell carcinomas by promoting cancer stemness via expression of oct4. Oncotarget 10 (23): 2306-2319.
    • Hu L, et al. (2019) Reduced compensatory β-cell proliferation in nfatc3-deficient mice fed on high-fat diet. Exp Clin Endocrinol Diabetes
    • Filosa JA, et al. (2007) Activity-dependent nfatc3 nuclear accumulation in pericytes from cortical parenchymal microvessels. Am J Physiol Cell Physiol 293 (6): C1797-1805.
    • de Frutos S, et al. (2007) Nfatc3 mediates chronic hypoxia-induced pulmonary arterial remodeling with alpha-actin up-regulation. J Biol Chem 282 (20): 15081-15089.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.