NF-M/NEFM Antibodies, cDNA Clones Research Reagents

NEFM (Neurofilament Medium, also known as NFM; NEF3; NF-M), located on 8p21.2, is a Protein Coding gene. Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. The gene produces a 102472 Da protein composed of 916 amino acids. NEFM is an intermediate-sized cytoskeletal neurofilament that localizes to neuronal axons and dendrites. This protein is commonly used as a biomarker of neuronal damage. Diseases such as Charcot-Marie-Tooth Disease, Demyelinating, Type 1F, and Charcot-Marie-Tooth Disease, Axonal, Type 2E are associated with NEFM.

NF-M/NEFM Antibody (1)

    NF-M/NEFM cDNA Clone (17)

    NM_001105541.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_008691.2

    In expression vector

    NF-M/NEFM qPCR Primer (1)

    ほかの人気製品

    NF-M/NEFM の背景知識

    NEFM (Neurofilament Medium) is a Protein Coding gene. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity). Alternative splicing results in multiple transcript variants encoding distinct isoforms. Diseases associated with NEFM include Charcot-Marie-Tooth Disease, Demyelinating, Type 1F, and Charcot-Marie-Tooth Disease, Axonal, Type 2E. Among its related pathways are Neuroscience and Association Between Physico-Chemical Features and Toxicity Associated Pathways.

    NF-M/NEFM の参考文献

    • Taylor JP, et al. (2001) Transcription of intermediate filament genes is enhanced in focal cortical dysplasia. Acta Neuropathol 102 (2): 141-148.
    • Strous RD, et al. (2007) Association of the dopamine receptor interacting protein gene, nef3, with early response to antipsychotic medication. Int J Neuropsychopharmacol 10 (3): 321-333.
    • Krüger R, et al. (2003) Mutation analysis of the neurofilament m gene in parkinson's disease. Neurosci Lett 351 (2): 125-129.

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