Neuropilin-2 Proteins, Antibodies, cDNA Clones, ELISA Kits Research Reagents

NRP2 (Neuropilin 2, also known as NP2; NPN2; PRO2714; VEGF165R2), located on 2q33.3, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 104831 Da protein composed of 931 amino acids. This gene encodes a member of the neuropilin family of receptor proteins. NRP2 is broadly expressed in the placenta, ovary, and other tissues. Diseases such as Wallerian Degeneration and Exudative Vitreoretinopathy 1 are associated with NRP2. The related pathways of NRP2 include Neuroscience and Signaling by GPCR.

Neuropilin-2 Protein (3)

    Neuropilin-2 Antibody (5)

      Neuropilin-2 ELISA キット(すぐに使用できます)& ELISA抗体ペアセット(すぐに使用できません)(2)

      Neuropilin-2 cDNA Clone (14)

      NM_201266.2

      In expression vector

      NM_001077404.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      Neuropilin-2 Lysate (3)

        Neuropilin-2 の背景知識

        Neuropilin-2 (NRP-2) which is related to NRP-1, is a type I? transmembrane glycoprotein and has the structure characteristic with five main extracellular domains: two complement binding (CUB) domains, two coagulation factor V/VIII homology domains, and a MAM (meprin, tyrosine phosphatase domain) region. NRP-2 is a receptor capable of binding two disparate ligands, classⅢ semaphorins (SEMA) and vascular endothelial growth factors (VEGF), and thus regulates two diverse systems by activating cellular signaling pathways via interacting with other cell surface receptors such as VEGF receptors and plexins. NRP-2 is well known for its role in facilitating axonal guidance during the development of the neuronal system, and additionally, it is also expressed in vascular endothelial cells and lymphatic endothelium where it affects proliferation, migration, angiogenesis, as well as the formation of small lymphatic vessels and capillaries. A recent study has identified NRP-2 as a polysialylation protein expressed in human dendritic cells and modulates DC-T Cell Interactions. Nearly all tumor cells express neuropilins and NRP-2 is predominantly expressed in neuronal tumors and melanomas. Furthermore, it is suggested that as the specific ligand for NRP-2, SEMA 3F inhibits tumor angiogenesis, and metastasis.

        Neuropilin-2 の参考文献

        • Chen H. et al., 1997, Neuron. 19: 547-59.
        • Bielenberg DR. et al., 2006, Exp Cell Res. 312: 584-93.
        • Yuan L. et al., 2002, Development. 129: 4797-806.
        • Benoit F. et al., 2006, Blood. 108: 1243-50.
        • Sabrina C. et al., 2007, J Biol Chem. 282: 30346-56.
        • Gray MJ. et al., 2008, J Natl Cancer Inst. 100: 109-20.

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