Neuroligin 3/NLGN3 Proteins, Antibodies, cDNA Clones Research Reagents

NLGN3 (Neuroligin 3, also known as HNL3), located on Xq13.1, is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, and frog. The gene produces a 93895 Da protein composed of 848 amino acids. This gene encodes a member of a family of neuronal cell surface proteins. Neuroligins mediate cell-to-cell interactions between neurons. Diseases such as Asperger Syndrome, X-Linked 1, and Autism X-Linked 1 are associated with NLGN3. The related pathways of NLGN3 include Cell adhesion molecules (CAMs) and Protein-protein interactions at synapses.

Neuroligin 3/NLGN3 Protein (1)

    Neuroligin 3/NLGN3 Antibody (5)

      Neuroligin 3/NLGN3 cDNA Clone (13)


      クローニングベクター cDNA 製品

      In lentiviral vector

      Neuroligin 3/NLGN3 qPCR Primer (1)

      Neuroligin 3/NLGN3 Lysate (1)

        Neuroligin 3/NLGN3 の背景知識

        Neuroligin 3 (NLGN3) is a member of the type-B carboxylesterase/lipase family. Neuroligins (NLGNs) are a family of presumptive postsynaptic cell adhesion molecules. Neuroligins (NLs) constitute a family of cell-surface proteins that interact with neurexins (beta-Nxs), another class of neuronal cell-surface proteins, one of each class functioning together in synapse formation. Neuroligins control the formation and functional balance of excitatory and inhibitory synapses in hippocampal neurons. NLGN1 and NLGN2 isoforms are concentrated at glutamatergic and GABAergic synapses, respectively, but the cellular expression and synaptic localization of the endogenous. NLGN3 was enriched in the brain, where NLGN3 protein levels increased during postnatal development, coinciding with the peak of synaptogenesis. The NLGN3 is a synaptic adhesion molecule that is a shared component of glutamatergic and GABAergic synapses. Mutations in the NLGN3 gene may be associated with autism and Asperger syndrome.

        Neuroligin 3/NLGN3 の参考文献

        • Chih B, et al. (2005) Control of excitatory and inhibitory synapse formation by neuroligins. Science. 307(5713): 1324-8.
        • Paraoanu LE, et al. (2006) Expression patterns of neurexin-1 and neuroligins in brain and retina of the chick embryo: Neuroligin-3 is absent in retina. Neurosci Lett. 395(2): 114-7.
        • Budreck EC, et al. (2007) Neuroligin-3 is a neuronal adhesion protein at GABAergic and glutamatergic synapses. Eur J Neurosci. 26(7): 1738-48.

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