Neuroligin 1 Proteins, Antibodies, cDNA Clones Research Reagents

NLGN1 (Neuroligin 1, also known as NL1), located on 3q26.31, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 96368 Da protein composed of 863 amino acids. The NLGN1 gene encodes a transmembrane protein that belongs to the NLGN family of cell-adhesion molecules. Diseases such as Autism 20 and Asperger Syndrome are associated with NLGN1. The related pathways of NLGN1 include Ectoderm Differentiation and Cell adhesion molecules (CAMs).

Neuroligin 1 Protein (2)

    Neuroligin 1 Antibody (4)

      Neuroligin 1 cDNA Clone (27)

      NM_014932.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_138666.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      XM_015445535.1

      クローニングベクター cDNA 製品

      Neuroligin 1 Lysate (2)

        Neuroligin 1 の背景知識

        Neuroligin 1 (NLGN1) belongs to the type-B carboxylesterase/lipase family, is a synaptic cell-adhesion molecule that is enriched in postsynaptic densities where it may recruit receptors, channels, and signal-transduction molecules to synaptic sites of cell adhesion. Neuroligins consists of five members (NLGN1, NLGN2, NLGN3, NLGN4, and NLGN4Y), which interact with beta-neurexins, and this interaction is involved in the formation of functional synapses. The extracellular domain of functional Neuroligin 1 associates as a dimer when analyzed by sedimentation equilibrium. Neuroligin 1 has a unique N-linked glycosylation pattern in the neuroligin family, and glycosylation and its processing modify neuroligin activity. Neuroligin 1 is a potent trigger for the de novo formation of synaptic connections, and it has recently been suggested that it is required for the maturation of functionally competent excitatory synapses. The persistent expression of Neuroligin 1 is required for the maintenance of NMDAR-mediated synaptic transmission, which enables the normal development of synaptic plasticity and long-term memory in the amygdala of adult animals.

        Neuroligin 1 の参考文献

        • Song JY, et al. (1999) Neuroligin 1 is a postsynaptic cell-adhesion molecule of excitatory synapses. Proc Natl Acad Sci U S A. 96(3): 1100-5.
        • Comoletti D, et al. (2003) Characterization of the interaction of a recombinant soluble neuroligin-1 with neurexin-1beta. J Biol Chem. 278(50): 50497-505.
        • Ylisaukko-oja T, et al. (2005) Analysis of four neuroligin genes as candidates for autism. Eur J Hum Genet. 13(12): 1285-92.
        • Kim J, et al. (2008) Neuroligin-1 is required for normal expression of LTP and associative fear memory in the amygdala of adult animals. Proc Natl Acad Sci U S A. 105(26): 9087-92.
        • Schapitz IU, et al. (2010) Neuroligin 1 is dynamically exchanged at postsynaptic sites. J Neurosci. 30(38): 12733-44.

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