Neurogenin-3 Antibodies, cDNA Clones Research Reagents

NEUROG3 (Neurogenin 3, also known as ngn3; Atoh5; NGN-3; Math4B; bHLHa7), located on 10q22.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and frog. The gene produces a 23077 Da protein composed of 214 amino acids. The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. Diseases such as Diarrhea 4, Malabsorptive, Congenital, and Congenital Diarrhea are associated with NEUROG3. The related pathways of NEUROG3 include the Regulation of beta-cell development and Embryonic and Induced Pluripotent Stem Cells and Lineage-specific Markers.

Neurogenin-3 Antibody (1)

    Neurogenin-3 cDNA Clone (2)

    BC117488

    In expression vector

    In lentiviral vector

    Neurogenin-3 qPCR Primer (1)

    Neurogenin-3 の背景知識

    NEUROG3 (Neurogenin 3) is a Protein Coding gene. The protein encoded by this gene is a basic helix-loop-helix (bHLH) transcription factor involved in neurogenesis. The encoded protein likely acts as a heterodimer with another bHLH protein. Together with NKX2-2, it initiates transcriptional activation of NEUROD1. NEUROG3 plays a central role in the development of both pancreatic islets and enteroendocrine cells. Homozygous hypomorphic missense mutations in NEUROG3 have been recently associated with a rare form of congenital malabsorptive diarrhea secondary to enteroendocrine cell dysgenesis. NEUROG3 is essential for endocrine pancreas development in humans and that as little as 10% NEUROG3 is sufficient for the formation of pancreatic endocrine cells.

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