Neurofascin Proteins, Antibodies Research Reagents

NFASC (Neurofascin, also known as NF; NRCAML; NEDCPMD), located on 1q32.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 150027 Da protein composed of 1347 amino acids. This gene encodes an L1 family immunoglobulin cell adhesion molecule with multiple IGcam and fibronectin domains. Diseases such as Neurodevelopmental Disorder With Central And Peripheral Motor Dysfunction and Demyelinating Polyneuropathy are associated with NFASC. The related pathways of NFASC include Neuroscience and L1CAM interactions.

Neurofascin Protein (3)

    Neurofascin Antibody (2)

      Neurofascin Lysate (2)

        Neurofascin の背景知識

        NFASC (Neurofascin, also known as NRCAML, NEDCPMD, and NF) is a Protein Coding gene. 13 alternatively spliced human isoforms have been reported. NFASC belongs to the immunoglobulin superfamily, L1/neurofascin/NgCAM family. It contains 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains. The protein functions in neurite outgrowth, neurite fasciculation, and organization of the axon initial segment (AIS) and nodes of Ranvier on axons during early development. NFASC links the AIS extracellular matrix to the intracellular cytoskeleton. It is broadly expressed in the brain, kidney, and other tissues. Diseases associated with NFASC include Neurodevelopmental Disorder With Central And Peripheral Motor Dysfunction and Demyelinating Polyneuropathy.

        Neurofascin の参考文献

        • Volkmer H. et al., 1992, J Cell Biol. 118 (1): 149-61.
        • Burmeister M. et al., 1996, Mamm Genome. 7 (7): 558-9.
        • Ango F. et al., 2004, Cell. 119 (2): 257-72.

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