NEU2 Proteins, cDNA Clones Research Reagents

NEU2 (Neuraminidase 2, also known as SIAL2), located on 2q37.1, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, and chicken. The gene produces a 42254 Da protein composed of 380 amino acids. This gene belongs to a family of glycohydrolytic enzymes that remove sialic acid residues from glycoproteins and glycolipids. Diseases such as Galactosialidosis and Discrete Subaortic Stenosis are associated with NEU2. The related pathways of NEU2 include Transport to the Golgi and subsequent modification and Other glycan degradation.

NEU2 Protein (1)

    NEU2 cDNA Clone (30)

    BC107053

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_015750.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NEU2 Lysate (1)

      NEU2 の背景知識

      Human sialidase 2 (NEU2) is a cytoplasmic sialidase that degrades sialyl glycoconjugates, including glycoproteins and gangliosides, via hydrolysis of terminal sialic acids to produce asialo-type molecules. It belongs to a family of glycohydrolytic enzymes that remove sialic acid residues from glycoproteins and glycolipids. NEU2 expression as assessed by quantitative real-time PCR was found to be extremely low or undetectable in many human tissues and cells, with notable exceptions like the placenta and testis. The human cytosolic sialidase NEU2 is the only mammalian enzyme structurally characterized and represents a valuable model to study the specificity of novel NA inhibitory drugs. Diseases associated with NEU2 include Galactosialidosis and Discrete Subaortic Stenosis.

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