NEK3 Proteins, Antibodies, cDNA Clones Research Reagents

NEK3 (NIMA Related Kinase 3, also known as HSPK36), located on 13q14.3, is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, chicken, zebrafish, A.thaliana, and frog. The gene produces a 57705 Da protein composed of 506 amino acids. This gene encodes a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Diseases such as Muscular Phosphorylase Kinase Deficiency and Glycogen Storage Disease Ia are associated with NEK3. The related pathways of NEK3 include Prolactin Signaling Pathway.

NEK3 Protein (1)

    NEK3 Antibody (1)

      NEK3 cDNA Clone (30)

      NM_152720.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      EF043796

      クローニングベクター cDNA 製品

      In lentiviral vector

      NEK3 Lysate (1)

        NEK3 の背景知識

        NEK3 (NIMA (never in mitosis gene a)-related expressed kinase 3), contains 1 protein kinase domain and is a member of the NimA (never in mitosis A) family of serine/threonine protein kinases. Members of the NEK family of protein kinases share high amino acid homology with NIMA (never in mitosis gene a). NEK3 differs from other NimA family members in that it is not the cell cycle-regulated and is found primarily in the cytoplasm. It is activated by prolactin stimulation, leading to phosphorylation of VAV2 guanine nucleotide exchange factor, paxillin, and activation of the RAC1 GTPase. NEK3 mRNA can be detected in all the proliferating cell lines with the amount not changing during the cell cycle. Prolactin stimulates interaction between NEK3 and paxillin leading to increased paxillin phosphorylation, Analysis of breast tissue microarrays show a significant up-regulation of NEK3 expression in malignant versus normal specimens. Multiple transcript variants encoding different isoforms have been found for the NEK3 gene. NEK3 may play a role in mitotic regulation.

        NEK3 の参考文献

        • Miller SL, et al. (2007) Nek3 kinase regulates prolactin-mediated cytoskeletal reorganization and motility of breast cancer cells. Oncogene. 26(32):4668-78.
        • Hernandez M, et al. (2006) Is there any association between nek3 and cancers with frequent 13q14 deletion?. Cancer Invest. 24(7):682-8.
        • Tanaka K, et al. (1999) Cloning and characterization of the murine Nek3 protein kinase, a novel member of the NIMA family of putative cell cycle regulators. J Biol Chem. 274(19):13491-7.

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