NEGR1 Proteins, Antibodies, cDNA Clones Research Reagents

NEGR1 (Neuronal Growth Regulator 1, also known as Ntra; KILON; IGLON4; DMML2433), located on 1p31.1, is a Protein Coding gene. The gene produces a 38719 Da protein composed of 354 amino acids. NEGR1 participates in the regulation of neurite outgrowth in the developing brain and is expressed on neurites of primary hippocampal neurons. It belongs to the immunoglobulin superfamily. Diseases such as Niemann-Pick Disease are associated with NEGR1. The related pathways of NEGR1 include the Metabolism of proteins and cell adhesion molecules (CAMs).

NEGR1 Protein (2)

    NEGR1 Antibody (1)

      NEGR1 cDNA Clone (26)

      NM_173808.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001039094.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NEGR1 Lysate (2)

        NEGR1 の背景知識

        Neuronal Growth Regulator 1, NEGR1, also known as neurotractin, or KILON, belongs to the immunoglobulin superfamily, IgLON family. This GPI-linked cell surface glycoprotein NEGR1 is composed of three Ig-like domains and belongs to the IgLON subgroup of neural IgSF members. It is expressed in two isoforms with apparent molecular masses of 50 and 37 kD, termed L-form and S-form, respectively. NEGR1/Neurotractin participates in the regulation of neurite outgrowth in the developing brain and is expressed on the neurites of primary hippocampal neurons. Neurotractin/KILON is a trans-neural growth-promoting factor for outgrowing axons following hippocampal denervation. KILON (kindred of IgLON) and opioid-binding cell adhesion molecule, together with the limbic system-associated membrane protein and neurotrophin, belong to the IgLON subgroup of immunoglobulin superfamily. The alteration of the modulatory function of KILON/NEGR1 for the number of dendritic synapses concomitant with changes in its localization and detergent solubility during neuronal culture development. In addition to its reported role in the brain, NEGR1 is also expressed in subcutaneous adipose tissue and acts as a central 'hub' in an obesity-related transcript network.

        NEGR1 の参考文献

        • Marg A, et al. (1999) Neurotractin, a novel neurite outgrowth-promoting Ig-like protein that interacts with CEPU-1 and LAMP. J Cell Biol. 145(4): 865-76.
        • Miyata S, et al. (2003) Biochemical and ultrastructural analyses of IgLON cell adhesion molecules, Kilon and OBCAM in the rat brain. Neuroscience. 117(3): 645-58.
        • Schfer M, et al. (2005) Neurotractin/kilon promotes neurite outgrowth and is expressed on reactive astrocytes after entorhinal cortex lesion. Mol Cell Neurosci. 29(4): 580-90.
        • Hashimoto T, et al. (2008) IgLON cell adhesion molecule Kilon is a crucial modulator for synapse number in hippocampal neurons. Brain Res. 1224: 1-11.

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