NEDD4 Antibodies, cDNA Clones Research Reagents

NEDD4 (NEDD4 E3 Ubiquitin Protein Ligase, also known as RPF1; NEDD4-1), located on 15q21.3, is a Protein Coding gene. This gene is the founding member of the NEDD4 family of HECT ubiquitin ligases that function in the ubiquitin-proteasome system of protein degradation. The gene produces a 149114 Da protein composed of 1319 amino acids. NEDD4 is an E3 ligase that degrades multiple different proteins and plays an oncogenic role in human cancer. Diseases such as Liddle Syndrome 1 and Pseudohypoaldosteronism are associated with NEDD4.

NEDD4 Antibody (1)

    NEDD4 cDNA Clone (30)

    NM_006154.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_010890.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_012986.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NEDD4 qPCR Primer (1)

    ほかの人気製品

    NEDD4 の背景知識

    Neural precursor cell expressed developmentally down-regulated protein 4 (NEDD4) is an E3 ligase that degrades multiple different proteins and plays an oncogenic role in human cancer. The Nedd4 family E3 ligases are key regulators of cell growth and proliferation and are often misregulated in human cancers and other diseases. The ligase activities of Nedd4 E3s are tightly controlled via auto-inhibition. Nedd4 deficiency promoted mouse death from sepsis and cell pyroptosis, resulting from non-canonical inflammasome activation. Furthermore, Nedd4 induced the K48-linked polyubiquitination and subsequent degradation of caspase-11 through the 26S proteasome. Meanwhile, caspase-11 (or caspase-4) reciprocally regulated the level of Nedd4 protein by cleavage. Thus, Nedd4 appears to have a key role in balancing the level of non-canonical inflammasome activation in response to gram-negative bacterial infection.

    NEDD4 の参考文献

    • Zhu K, et al. (2017) Allosteric auto-inhibition and activation of the nedd4 family e3 ligase itch. EMBO Rep 18 (9): 1618-1630.
    • Zhang J, et al. (2019) Diosgenin inhibits the expression of nedd4 in prostate cancer cells. Am J Transl Res 11 (6): 3461-3471.
    • Liu Q, et al. (2019) E3 ubiquitin ligase nedd4 is a key negative regulator for non-canonical inflammasome activation. Cell Death Differ 26 (11): 2386-2399.

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