Nectin 3 Proteins, Antibodies, cDNA Clones Research Reagents

NECTIN3 (Nectin Cell Adhesion Molecule 3) is a protein coding gene located on human chromosome 3q13.13. NECTIN3 is also known as PPR3, PRR3, CD113, PVRL3, PVRR3, CDW113 and NECTIN-3. The human NECTIN3 gene encodes a 61002 Da protein containing 549 amino acids. The NECTIN3 protein is broadly expressed in thyroid, testis and other tissues. Among its related pathways are Cell junction organization and Cell adhesion molecules (CAMs). NECTIN1 is an important paralog of NECTIN3 gene. NECTIN3 is associated with some diseases, including Cleft Lip/Palate-Ectodermal Dysplasia Syndrome and Clostridium Difficile Colitis.

Nectin 3 Protein (2)

    Nectin 3 Antibody (5)

      Nectin 3 cDNA Clone (25)

      NM_015480.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_021495.4

      Nectin 3 qPCR Primer (1)

      Nectin 3 Lysate (2)

        Nectin 3 の背景知識

        Poliovirus receptor-related 3 (PVRL3), also known as Nectin-3 and CD113, is a member of the nectin family. PVRL3/Nectin-3 is an 83 kDa, type I transmembrane glycoprotein. Its precursor is 549 amino acids (aa) in length and contains an extended signal sequence of 57 aa, an extracellular domain (ECD) of 347 aa, a transmembrane segment of 21 aa, and a cytoplasmic region of 124 aa. Nectin-3 has three splicing variants, nectin-3alpha (biggest), -3beta (middle), and -3gamma (smallest). It is predominantly expressed in testis and placenta as well as in various cell lines, including epithelial cell lines. PVRL3/Nectin-3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/Nectin-2 at Sertoli-spermatid junctions. PVRL3/Nectin-3 is thus involved in the formation of cell-cell junctions, including adherens junctions and synapses. It has been shown to induce endocytosis-mediated down-regulation of PVR from the cell surface, resulting in the reduction of cell movement and proliferation.

        Nectin 3 の参考文献

        • Satoh-Horikawa, et al. (2000). Nectin-3, a new member of immunoglobulin-like cell adhesion molecules that shows homophilic and heterophilic cell-cell adhesion activities. J Biol Chem (UNITED STATES) . 275 (14): 10291-9.
        • Reymond N, et al. (2000). Human nectin3/PRR3: a novel member of the PVR/PRR/nectin family that interacts with afadin. Gene (NETHERLANDS). 255 (2): 347-55.

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