NDUFV2 Antibodies, cDNA Clones Research Reagents

NDUFV2 (NADH: Ubiquinone Oxidoreductase Core Subunit V2, also known as CI-24k; MC1DN7), located on 18p11.22, is a Protein Coding gene. The NDUFV2 gene encodes the 24-kD subunit of the mitochondrial NADH: ubiquinone oxidoreductase (complex I of the respiratory chain). The gene produces a 27392 Da protein composed of 249 amino acids. The mitochondrial targeting sequence of NDUFV2 is located at the N-terminus of the precursor protein. The impairment of mitochondrial localization of NDUFV2 as a mechanistic basis for early-onset hypertrophic cardiomyopathy and encephalopathy.

NDUFV2 Antibody (2)

    NDUFV2 cDNA Clone (17)

    NM_021074.4

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_031064.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NDUFV2 の背景知識

    NDUFV2, located on 18p11.31-p11.2, encodes an important subunit of mitochondrial NADH (complex I). NADH dehydrogenase (ubiquinone) flavoprotein 2 (NDUFV2), containing one iron-sulfur cluster ([2Fe-2S] binuclear cluster N1a), is one of the core nuclear-encoded subunits existing in human mitochondrial complex I. Defects in this subunit have been associated with Parkinson's disease, Alzheimer's disease, Bipolar disorder, and Schizophrenia. The mitochondrial targeting sequence of NDUFV2 is located at the N-terminus of the precursor protein. Maintaining a net positive charge and an amphiphilic structure with the overall balance and distribution of basic and hydrophobic amino acids in the N-terminus of NDUFV2 is important for mitochondrial targeting. The results of the human disease cell model established that the impairment of mitochondrial localization of NDUFV2 as a mechanistic basis for early-onset hypertrophic cardiomyopathy and encephalopathy.

    NDUFV2 の参考文献

    • Zhang J, et al. (2009) Association study on the mitochondrial gene ndufv2 and bipolar disorder in the chinese han population. J Neural Transm (Vienna) 116 (3): 357-361.
    • Nishioka K, et al. (2010) Genetic variation of the mitochondrial complex i subunit ndufv2 and parkinson's disease. Parkinsonism Relat Disord 16 (10): 686-687.
    • Liu HY, et al. (2011) Mitochondrial targeting of human nadh dehydrogenase (ubiquinone) flavoprotein 2 (ndufv2) and its association with early-onset hypertrophic cardiomyopathy and encephalopathy. J Biomed Sci 18 (1): 29.

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