NDUFS6 Antibodies, cDNA Clones Research Reagents

NDUFS6 (NADH: Ubiquinone Oxidoreductase Subunit S6, also known as MC1DN9; CI-13kA; CI13KDA; CI-13kD-A), located on 5p15.33, is a Protein Coding gene. NDUFS6 gene encodes a subunit of the NADH: ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. NDUFS6 belongs to the complex I NDUFS6 subunit family. The predicted 124-amino acid human NDUFS6 protein shares 83% identity with the bovine 13-kD protein. The first 28 amino acids of human NDUFS6 comprise a possible mitochondrial targeting sequence.

NDUFS6 Antibody (1)

    NDUFS6 cDNA Clone (17)

    NM_004553.4

    In expression vector

    NM_010888.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NDUFS6 qPCR Primer (1)

    NDUFS6 の背景知識

    NDUFS6 (NADH: Ubiquinone Oxidoreductase Subunit S6) is a Protein Coding gene. The NDUFS6 gene, located on 5p15.33, is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat, etc. NDUFS6 belongs to the complex I NDUFS6 subunit family. This gene encodes a subunit of the NADH: ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. NDUFS6 encodes a 13 kiloDaltons subunit, which is part of the peripheral arm of complex I and is localized in the iron-sulfur fraction. Diseases associated with NDUFS6 include Mitochondrial Complex I Deficiency, Nuclear Type 9, and Mitochondrial Complex I Deficiency, Nuclear Type 1. Among its related pathways are GABAergic synapse and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

    NDUFS6 の参考文献

    • Rouzier C, et al. (2019) Ndufs6 related leigh syndrome: A case report and review of the literature. J Hum Genet 64 (7): 637-645.
    • Kirby DM, et al. (2004) Ndufs6 mutations are a novel cause of lethal neonatal mitochondrial complex i deficiency. J Clin Invest 114 (6): 837-845.
    • Ke BX, et al. (2012) Tissue-specific splicing of an ndufs6 gene-trap insertion generates a mitochondrial complex i deficiency-specific cardiomyopathy. Proc Natl Acad Sci U S A 109 (16): 6165-6170.

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