NDUFS6 (NADH: Ubiquinone Oxidoreductase Subunit S6) is a Protein Coding gene. The NDUFS6 gene, located on 5p15.33, is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat, etc. NDUFS6 belongs to the complex I NDUFS6 subunit family. This gene encodes a subunit of the NADH: ubiquinone oxidoreductase (complex I), which is the first enzyme complex in the electron transport chain of mitochondria. This complex functions in the transfer of electrons from NADH to the respiratory chain. NDUFS6 encodes a 13 kiloDaltons subunit, which is part of the peripheral arm of complex I and is localized in the iron-sulfur fraction. Diseases associated with NDUFS6 include Mitochondrial Complex I Deficiency, Nuclear Type 9, and Mitochondrial Complex I Deficiency, Nuclear Type 1. Among its related pathways are GABAergic synapse and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.