NDUFB9 Antibodies, cDNA Clones Research Reagents

NDUFB9 (NADH: Ubiquinone Oxidoreductase Subunit B9, also known as B22; LYRM3; CI-B22; UQOR22; MC1DN24), located on 8q24.13, is a Protein Coding gene. NDUFB9 is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). It belongs to the complex I LYR family. The NDUFB9 protein weighs 22 kDa and is composed of 179 amino acids. NDUFB9 is considered a candidate gene for branchio-oto-renal (BOR) syndrome and is down-regulated in highly metastatic breast cancer cells.

NDUFB9 Antibody (1)

    NDUFB9 cDNA Clone (31)

    NM_005005.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_023172.3

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001127294.2

    クローニングベクター cDNA 製品

    NDUFB9 の背景知識

    NDUFB9 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Human NADH dehydrogenase (ubiquinone) 1beta-subcomplex, 9 (NDUFB9) is a nuclear-encoded mitochondrial protein with the respiratory electron transport chain. It has been physically mapped to a 1-Mb deletion at chromosome 8q13 which also contains the gene for branchio-oto-renal (BOR) syndrome. BOR syndrome is characterized by branchial and renal abnormalities with hearing impairment. Since several hereditary deafness disorders have been associated with mitochondrial mutations, NDUFB9 was considered a candidate gene for BOR syndrome. NDUFB9 is down-regulated in highly metastatic breast cancer cells. Mutant NDUFB9 is a new cause of complex I deficiency.

    NDUFB9 の参考文献

    • Lin X, et al. (1999) Human ndufb9 gene: Genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13. Hum Hered 49 (2): 75-80.
    • Li LD, et al. (2015) Down-regulation of ndufb9 promotes breast cancer cell proliferation, metastasis by mediating mitochondrial metabolism. PLoS One 10 (12): e0144441.

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