NDUFB9 Antibodies, cDNA Clones Research Reagents

NDUFB9 (NADH: Ubiquinone Oxidoreductase Subunit B9, also known as B22; LYRM3; CI-B22; UQOR22; MC1DN24), located on 8q24.13, is a Protein Coding gene. NDUFB9 is a subunit of the mitochondrial oxidative phosphorylation complex I (nicotinamide adenine dinucleotide: ubiquinone oxidoreductase). It belongs to the complex I LYR family. The NDUFB9 protein weighs 22 kDa and is composed of 179 amino acids. NDUFB9 is considered a candidate gene for branchio-oto-renal (BOR) syndrome and is down-regulated in highly metastatic breast cancer cells.

NDUFB9 Antibody (1)

    NDUFB9 cDNA Clone (31)


    クローニングベクター cDNA 製品

    In lentiviral vector


    クローニングベクター cDNA 製品

    In lentiviral vector


    クローニングベクター cDNA 製品

    NDUFB9 の背景知識

    NDUFB9 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (complex I). Human NADH dehydrogenase (ubiquinone) 1beta-subcomplex, 9 (NDUFB9) is a nuclear-encoded mitochondrial protein with the respiratory electron transport chain. It has been physically mapped to a 1-Mb deletion at chromosome 8q13 which also contains the gene for branchio-oto-renal (BOR) syndrome. BOR syndrome is characterized by branchial and renal abnormalities with hearing impairment. Since several hereditary deafness disorders have been associated with mitochondrial mutations, NDUFB9 was considered a candidate gene for BOR syndrome. NDUFB9 is down-regulated in highly metastatic breast cancer cells. Mutant NDUFB9 is a new cause of complex I deficiency.

    NDUFB9 の参考文献

    • Lin X, et al. (1999) Human ndufb9 gene: Genomic organization and a possible candidate gene associated with deafness disorder mapped to chromosome 8q13. Hum Hered 49 (2): 75-80.
    • Li LD, et al. (2015) Down-regulation of ndufb9 promotes breast cancer cell proliferation, metastasis by mediating mitochondrial metabolism. PLoS One 10 (12): e0144441.

    Note: Flag® is a registered trademark of Sigma Aldrich Biotechnology LP. It is used here for informational purposes only.