NDUFA3 Antibodies, cDNA Clones Research Reagents

NDUFA3 (NADH: Ubiquinone Oxidoreductase Subunit A3, also known as B9; CI-B9), located on 19q13.42, is a Protein Coding gene. NDUFA3 is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. The immediate electron acceptor for the enzyme is believed to be ubiquinone. NDUFA3 belongs to the complex I NDUFA3 subunit family and is ubiquitously expressed in kidney, fat, and other tissues. The predicted 84-amino acid human protein shares 83% identity with bovine B9.

NDUFA3 Antibody (1)

    NDUFA3 cDNA Clone (17)

    NM_004542.3

    In expression vector

    XM_002725503.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NDUFA3 qPCR Primer (1)

    NDUFA3 の背景知識

    NDUFA3 (NADH: Ubiquinone Oxidoreductase Subunit A3) is a Protein Coding gene. The NDUFA3 gene, located on 19q13.42, is conserved in chimpanzee, Rhesus monkey, cow, mouse, rat, zebrafish, and frog. NDUFA3 belongs to the complex I NDUFA3 subunit family. The encoded protein is an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. NDUFA3 is widely expressed in the kidney, fat, and other tissues. Diseases associated with NDUFA3 include Schizophrenia 5 and Periodontosis. Among its related pathways are GABAergic synapse and Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

    NDUFA3 の参考文献

    • Stroud DA, et al. (2016) Accessory subunits are integral for assembly and function of human mitochondrial complex i. Nature 538 (7623): 123-126.
    • Rak M, et al. (2014) Supernumerary subunits ndufa3, ndufa5 and ndufa12 are required for the formation of the extramembrane arm of human mitochondrial complex i. FEBS Lett 588 (9): 1832-1838.
    • Murray J, et al. (2003) The subunit composition of the human nadh dehydrogenase obtained by rapid one-step immunopurification. J Biol Chem 278 (16): 13619-13622.

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