NDRG4 Antibodies, cDNA Clones Research Reagents

NDRG4 (NDRG Family Member 4, also known as BDM1; SMAP8; SMAP-8), located on 16q21, is a Protein Coding gene. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signaling in vascular smooth muscle cells. NDRG4 belongs to the NDRG family. The deduced 371-amino acid protein has a calculated molecular mass of 40.7 kD. NDRG4 is a tumor suppressor that participates in cell survival, tumor invasion, and angiogenesis.

NDRG4 Antibody (1)

    NDRG4 cDNA Clone (32)

    BC011795

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_001195006.1

    クローニングベクター cDNA 製品

    In lentiviral vector

    NM_031967.2

    クローニングベクター cDNA 製品

    In lentiviral vector

    NDRG4 qPCR Primer (1)

    NDRG4 の背景知識

    N-Myc downstream-regulated gene 4 (NDRG4) is predominantly expressed in the brain as well as in the heart and has been reported to be involved in resistance to neuronal cell death caused by ischemic injury. NDRG4 is a member of the N-Myc downregulated gene family (NDRG) belonging to the alpha/beta hydrolase superfamily. NDRG4 plays an important role in biological processes and pathogenesis. For example, NDRG4 is a tumor suppressor that participates in cell survival, tumor invasion, and angiogenesis. As a novel candidate tumor suppressor, NDRG4 can inhibit PI3K/AKT signal which is related to energy balance and related carcinogenesis. NDRG4 is a candidate tumor suppressor gene in colorectal cancer whose expression is frequently inactivated by promoter methylation. NDRG4 promoter methylation is a potential biomarker for the noninvasive detection of colorectal cancer in stool samples.

    NDRG4 の参考文献

    • Zhu M, et al. (2017) Ndrg4 promotes myogenesis via akt/creb activation. Oncotarget 8 (60): 101720-101734.
    • Zheng J, et al. (2016) Ndrg4 stratifies the prognostic value of body mass index in colorectal cancer. Oncotarget 7 (2): 1311-1322.
    • Wen L, et al. (2019) Ndrg4 protects against cerebral ischemia injury by inhibiting p53-mediated apoptosis. Brain Res Bull 146 104-111.
    • Melotte V, et al. (2009) N-myc downstream-regulated gene 4 (ndrg4): A candidate tumor suppressor gene and potential biomarker for colorectal cancer. J Natl Cancer Inst 101 (13): 916-927.

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