NDRG1 Proteins, Antibodies, cDNA Clones Research Reagents

NDRG1 (N-Myc Downstream Regulated 1, also known as GC4; RTP; DRG1; NDR1; NMSL; TDD5; CAP43; CMT4D; DRG-1; HMSNL; RIT42; TARG1; PROXY1), located on 8q24.22, is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog. The gene produces a 42835 Da protein composed of 394 amino acids. This gene is a member of the N-Myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. Diseases such as Charcot-Marie-Tooth Disease, Type 4D and Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive are associated with NDRG1. The related pathways of NDRG1 include Neuroscience and Validated targets of C-MYC transcriptional repression.

NDRG1 Protein (1)

    NDRG1 Antibody (3)

      NDRG1 cDNA Clone (32)

      BC003175

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_008681.2

      クローニングベクター cDNA 製品

      In lentiviral vector

      NM_001011991.1

      クローニングベクター cDNA 製品

      In lentiviral vector

      NDRG1 qPCR Primer (1)

      NDRG1 の背景知識

      NDRG1 gene is a member of the N-Myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. NDRG1 is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. NDRG1 is necessary for p53-mediated caspase activation and apoptosis. Mutations in the NDRG1 gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. NDRG1 is a stress-responsive protein involved in hormone responses, cell growth, and differentiation. It acts as a tumor suppressor in many cell types.

      NDRG1 の参考文献

      • Kachhap SK, et al. (2007) The N-Myc down regulated Gene1 (NDRG1) Is a Rab4a effector involved in vesicular recycling of E-cadherin. PLoS ONE. 2(9):e844.
      • Zhang J, et al. (2008) Human differentiation-related gene NDRG1 is a Myc downstream-regulated gene that is repressed by Myc on the core promoter region. Gene. 417(1-2):5-12.
      • Kokame K, et al. (1997) Homocysteine-respondent genes in vascular endothelial cells identified by differential display analysis. GRP78/BiP and novel genes. J Biol Chem. 271(47): 29659-65.

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