NCOR2 Antibodies, cDNA Clones Research Reagents

NCOR2 (Nuclear Receptor Corepressor 2) is a protein coding gene located on human chromosome 12q24.31. NCOR2 is also known as SMRT, TRAC, CTG26, SMRTE, TRAC1, N-CoR2, TNRC14, TRAC-1, SMAP270 and SMRTE-tau. The human NCOR2 gene encodes a 273657 Da protein containing 2514 amino acids. The NCOR2 protein is ubiquitously expressed in fat, lung and other tissues. Among its related pathways are Signaling by GPCR and Development NOTCH1-mediated pathway for NF-KB activity modulation. NCOR2 is related to sequence-specific DNA binding. NCOR1 is an important paralog of NCOR2 gene. NCOR2 is associated with some diseases, including Acute Promyelocytic Leukemia and Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema.

NCOR2 Antibody (1)

    NCOR2 cDNA Clone (1)

    NM_001077261.3

    In expression vector

    NCOR2 の背景知識

    The human nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand. NCOR2/SMRT is associated with poor patient outcomes, independent of other prognostic factors. A novel splice variant of the ERalpha corepressor NCOR2 as a candidate biomarker in breast cancer that not only predicts tamoxifen response but may be targeted to overcome tamoxifen resistance.

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