NCOR2 Antibodies, cDNA Clones Research Reagents

All NCOR2 reagents are produced in house and quality controlled, including 1 NCOR2 Antibody, 1 NCOR2 Gene. All NCOR2 reagents are ready to use.

NCOR2 Antibody (1)

    NCOR2 cDNA Clone (1)

    NM_001077261.3

    In expression vector

    NCOR2 の背景知識

    The human nuclear co-repressor 2 (N-CoR2) gene (NCOR2, previously called silencing mediator for retinoid and thyroid hormone receptor SMRT) is recruited to nuclear and non-nuclear receptors in a large repressing complex containing also N-CoR1, mSin3 and HDACs. This large complex represses transcription in absence of ligand.NCOR2/SMRT is associated with poor patient outcome, independent of other prognostic factors. A novel splice variant of the ERalpha corepressor NCOR2 as a candidate biomarker in breast cancer that not only predicts tamoxifen response but may be targeted to overcome tamoxifen resistance.

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