NCF1 Antibodies, cDNA Clones Research Reagents

NCF1 (Neutrophil Cytosolic Factor 1, also known as CGD1; NCF1A; NOXO2; p47phox; SH3PXD1A), located on 7q11.23, is a Protein Coding gene. The p47-phox (phagocyte oxidase) protein encoded by this gene is a 47 kDa cytosolic subunit of neutrophil NADPH oxidase. NCF1 is a component of the leukocyte NADPH oxidase complex mediating the formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. Genetic variability in the NCF1 gene is related to a higher chance of getting autoimmune diseases.

NCF1 Antibody (1)

    NCF1 cDNA Clone (15)

    BC002816

    クローニングベクター cDNA 製品

    In lentiviral vector

    NCF1 qPCR Primer (1)

    NCF1 の背景知識

    Neutrophil cytosolic factor 1, p47phox (NCF1) is a component of the leukocyte NADPH oxidase complex mediating the formation of reactive oxygen intermediates (ROI) which play an important role in host defense and autoimmunity. NCF1 is critical for microbicidal activity. The human p47-phox gene has been well characterized and resides on chromosome 7q11. The start of transcription of the mouse gene has been localized to within 12 nucleotides of the translation start site, similar to the human ortholog. The NCF1 gene colocalizes with two pseudogenes (NCF1B and NCF1C). These two pseudogenes have a GT deletion in exon 2, resulting in a frameshift and an early stop codon. An individual genomic pattern of ncf1 and its two types of pseudogenes (reflected by the DeltaGT/GTGT ratio) may influence the individual capacity to produce ROI, but only marginally influence susceptibility to and outcome of malaria and MS.

    NCF1 の参考文献

    • Greve B, et al. (2008) Ncf1 gene and pseudogene pattern: Association with parasitic infection and autoimmunity. Malar J 7 251.
    • DeSilva U, et al. (2000) Molecular characterization of the mouse p47-phox (ncf1) gene and comparative analysis of the mouse p47-phox (ncf1) gene to the human ncf1 gene. Mol Cell Biol Res Commun 3 (4): 224-230.
    • Brunson T, et al. (2010) A copy number variation in human ncf1 and its pseudogenes. BMC Genet 11 13.

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